Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2850766..2852354 Replicon chromosome
Accession NZ_CP074541
Organism Klebsiella pneumoniae strain S24_CRE24

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag KHV99_RS14055 Protein ID WP_002904792.1
Coordinates 2850766..2852088 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag KHV99_RS14060 Protein ID WP_002904790.1
Coordinates 2852088..2852354 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV99_RS14040 (KHV99_13995) 2845822..2848323 + 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -
KHV99_RS14045 (KHV99_14000) 2848311..2849315 + 1005 WP_002904798.1 fimbrial protein -
KHV99_RS14050 (KHV99_14005) 2849457..2850749 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
KHV99_RS14055 (KHV99_14010) 2850766..2852088 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
KHV99_RS14060 (KHV99_14015) 2852088..2852354 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KHV99_RS14065 (KHV99_14020) 2852620..2852946 - 327 WP_002904788.1 hydroxyisourate hydrolase -
KHV99_RS14070 (KHV99_14025) 2852943..2853443 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
KHV99_RS14075 (KHV99_14030) 2853421..2854800 - 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
KHV99_RS14080 (KHV99_14035) 2855146..2856300 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
KHV99_RS14085 (KHV99_14040) 2856281..2857204 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T202330 WP_002904792.1 NZ_CP074541:c2852088-2850766 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T202330 NZ_CP099375:c4296023-4295736 [Citrobacter braakii]
ATGCCAATGGAGTTTGAGTGGGATGCAAACAAGGCACAAAGTAACCACCGTAAACATGGTATTCGCTTTGAGGACGCAAT
ATTGGTTTTCGACGATCCCCAACATCTGTCGCGGCAGGATCGGTATGAGAACGGTGAGTATCGCTGGCAGACCATTGGTC
TCGTTCATGGCATTGTGGTTATTCTGGTTGCCCATAGCGTTAGGTTTGAAAGTGGCTTTGAAGTCATTCGTATCATCAGT
GCCAGAAAGGCAGATCGTAAAGAGAGGAGTCGTTATGAACATAGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT202330 WP_002904790.1 NZ_CP074541:c2852354-2852088 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT202330 NZ_CP099375:c4295749-4295447 [Citrobacter braakii]
ATGAACATAGTTAAACATAAACGCGGCAGCGTATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
TAAACCGGACGATGATATTGATTACAGCGACATTCCCGTGACCGAGGATGAGCTGTGGTCAGAAGCTCATCGCGGTAAGT
TTTTCCGTCCGTTGAAAACGCAGGCGTCGGTACGCATTGATGCCGATGTGATGGAATGGCTGAAGCGCCCCGGGAAGGGT
TACCAGACGCGTCTCAATGCCATTTTGCGCGAAGCGATGCTGCGCGAGCAAAACAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References