Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 870371..871028 | Replicon | chromosome |
Accession | NZ_CP074541 | ||
Organism | Klebsiella pneumoniae strain S24_CRE24 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | W8UCT0 |
Locus tag | KHV99_RS04400 | Protein ID | WP_002916310.1 |
Coordinates | 870618..871028 (+) | Length | 137 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | W8UQ37 |
Locus tag | KHV99_RS04395 | Protein ID | WP_002916312.1 |
Coordinates | 870371..870637 (+) | Length | 89 a.a. |
Genomic Context
Location: 867857..868168 (312 bp)
Type: Others
Protein ID: WP_002916319.1
Type: Others
Protein ID: WP_002916319.1
Location: 868332..868991 (660 bp)
Type: Others
Protein ID: WP_002916317.1
Type: Others
Protein ID: WP_002916317.1
Location: 870371..870637 (267 bp)
Type: Antitoxin
Protein ID: WP_002916312.1
Type: Antitoxin
Protein ID: WP_002916312.1
Location: 870618..871028 (411 bp)
Type: Toxin
Protein ID: WP_002916310.1
Type: Toxin
Protein ID: WP_002916310.1
Location: 871657..872553 (897 bp)
Type: Others
Protein ID: WP_004144729.1
Type: Others
Protein ID: WP_004144729.1
Location: 872576..873289 (714 bp)
Type: Others
Protein ID: WP_002916301.1
Type: Others
Protein ID: WP_002916301.1
Location: 873295..875028 (1734 bp)
Type: Others
Protein ID: WP_004151783.1
Type: Others
Protein ID: WP_004151783.1
Location: 865527..866960 (1434 bp)
Type: Others
Protein ID: WP_002916322.1
Type: Others
Protein ID: WP_002916322.1
Location: 867079..867807 (729 bp)
Type: Others
Protein ID: WP_002916321.1
Type: Others
Protein ID: WP_002916321.1
Location: 869142..870125 (984 bp)
Type: Others
Protein ID: WP_002916313.1
Type: Others
Protein ID: WP_002916313.1
Location: 871035..871556 (522 bp)
Type: Others
Protein ID: WP_002916308.1
Type: Others
Protein ID: WP_002916308.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KHV99_RS04370 (KHV99_04365) | 865527..866960 | - | 1434 | WP_002916322.1 | 6-phospho-beta-glucosidase BglA | - |
KHV99_RS04375 (KHV99_04370) | 867079..867807 | - | 729 | WP_002916321.1 | MurR/RpiR family transcriptional regulator | - |
KHV99_RS04380 (KHV99_04375) | 867857..868168 | + | 312 | WP_002916319.1 | N(4)-acetylcytidine aminohydrolase | - |
KHV99_RS04385 (KHV99_04380) | 868332..868991 | + | 660 | WP_002916317.1 | hemolysin III family protein | - |
KHV99_RS04390 (KHV99_04385) | 869142..870125 | - | 984 | WP_002916313.1 | tRNA-modifying protein YgfZ | - |
KHV99_RS04395 (KHV99_04390) | 870371..870637 | + | 267 | WP_002916312.1 | FAD assembly factor SdhE | Antitoxin |
KHV99_RS04400 (KHV99_04395) | 870618..871028 | + | 411 | WP_002916310.1 | protein YgfX | Toxin |
KHV99_RS04405 (KHV99_04400) | 871035..871556 | - | 522 | WP_002916308.1 | flavodoxin FldB | - |
KHV99_RS04410 (KHV99_04405) | 871657..872553 | + | 897 | WP_004144729.1 | site-specific tyrosine recombinase XerD | - |
KHV99_RS04415 (KHV99_04410) | 872576..873289 | + | 714 | WP_002916301.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
KHV99_RS04420 (KHV99_04415) | 873295..875028 | + | 1734 | WP_004151783.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 16049.85 Da Isoelectric Point: 11.4778
>T202321 WP_002916310.1 NZ_CP074541:870618-871028 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
Download Length: 411 bp
>T202321 NZ_CP099374:c4400486-4400205 [Citrobacter braakii]
ATGACCTATAACCTGGAGTTTTTAGATGTTGCGCTCAAGGAGTGGCGCAAGCTTTCCCCTGCATTACGTGAACAGTTCAA
AAAGAAACTGGCGGAGCGACTGGAAAATCCCCATGTTCCTGCTGCCCGCCTTTCCGGCAAATTACATCGTTACAAAATCA
AGCTACGCAGTGCTGGGTATCGTCTGGTCTATCAGGTCGAGGACGAGCAGGTTGTCGTTCTTGTGATCGCAGTAGGCAGA
CGTGATGGCGATGAGGTTTATCATCAGGCTAACCGGCGCTAG
ATGACCTATAACCTGGAGTTTTTAGATGTTGCGCTCAAGGAGTGGCGCAAGCTTTCCCCTGCATTACGTGAACAGTTCAA
AAAGAAACTGGCGGAGCGACTGGAAAATCCCCATGTTCCTGCTGCCCGCCTTTCCGGCAAATTACATCGTTACAAAATCA
AGCTACGCAGTGCTGGGTATCGTCTGGTCTATCAGGTCGAGGACGAGCAGGTTGTCGTTCTTGTGATCGCAGTAGGCAGA
CGTGATGGCGATGAGGTTTATCATCAGGCTAACCGGCGCTAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 10480.98 Da Isoelectric Point: 5.1116
>AT202321 WP_002916312.1 NZ_CP074541:870371-870637 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
Download Length: 267 bp
>AT202321 NZ_CP099374:c4400724-4400476 [Citrobacter braakii]
ATGCCATTTCATATCCTGACCAAAACCGCTGCCAGCATCACCGACCTGAAACGTAACCCAATGGGGACGGTCAACGCCGG
GGAGGGTGAAGCGGTGGCGATTCTGAACCGCAATGAGCCAGCGTTTTACTGCGTGCCGCCTGCGGTTTATGCGTATCTGC
TGGAGCTGGCAGAAGACGCCGAGCTGAACCGTATCGCCGACGAACGCGAAGGCGGAAAACGAATAAAGGTATCTTTAAAT
GACCTATAA
ATGCCATTTCATATCCTGACCAAAACCGCTGCCAGCATCACCGACCTGAAACGTAACCCAATGGGGACGGTCAACGCCGG
GGAGGGTGAAGCGGTGGCGATTCTGAACCGCAATGAGCCAGCGTTTTACTGCGTGCCGCCTGCGGTTTATGCGTATCTGC
TGGAGCTGGCAGAAGACGCCGAGCTGAACCGTATCGCCGACGAACGCGAAGGCGGAAAACGAATAAAGGTATCTTTAAAT
GACCTATAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GSW7 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GY41 |