Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870371..871028 Replicon chromosome
Accession NZ_CP074541
Organism Klebsiella pneumoniae strain S24_CRE24

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KHV99_RS04400 Protein ID WP_002916310.1
Coordinates 870618..871028 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KHV99_RS04395 Protein ID WP_002916312.1
Coordinates 870371..870637 (+) Length 89 a.a.

Genomic Context


KHV99_RS04380KHV99_RS04385KHV99_RS04395KHV99_RS04400KHV99_RS04410KHV99_RS04415KHV99_RS04420KHV99_RS04370KHV99_RS04375KHV99_RS04390KHV99_RS04405
Location: 867857..868168 (312 bp)
Type: Others
Protein ID: WP_002916319.1
Location: 868332..868991 (660 bp)
Type: Others
Protein ID: WP_002916317.1
Location: 870371..870637 (267 bp)
Type: Antitoxin
Protein ID: WP_002916312.1
Location: 870618..871028 (411 bp)
Type: Toxin
Protein ID: WP_002916310.1
Location: 871657..872553 (897 bp)
Type: Others
Protein ID: WP_004144729.1
Location: 872576..873289 (714 bp)
Type: Others
Protein ID: WP_002916301.1
Location: 873295..875028 (1734 bp)
Type: Others
Protein ID: WP_004151783.1
Location: 865527..866960 (1434 bp)
Type: Others
Protein ID: WP_002916322.1
Location: 867079..867807 (729 bp)
Type: Others
Protein ID: WP_002916321.1
Location: 869142..870125 (984 bp)
Type: Others
Protein ID: WP_002916313.1
Location: 871035..871556 (522 bp)
Type: Others
Protein ID: WP_002916308.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KHV99_RS04370 (KHV99_04365)865527..866960-1434WP_002916322.16-phospho-beta-glucosidase BglA-
KHV99_RS04375 (KHV99_04370)867079..867807-729WP_002916321.1MurR/RpiR family transcriptional regulator-
KHV99_RS04380 (KHV99_04375)867857..868168+312WP_002916319.1N(4)-acetylcytidine aminohydrolase-
KHV99_RS04385 (KHV99_04380)868332..868991+660WP_002916317.1hemolysin III family protein-
KHV99_RS04390 (KHV99_04385)869142..870125-984WP_002916313.1tRNA-modifying protein YgfZ-
KHV99_RS04395 (KHV99_04390)870371..870637+267WP_002916312.1FAD assembly factor SdhEAntitoxin
KHV99_RS04400 (KHV99_04395)870618..871028+411WP_002916310.1protein YgfXToxin
KHV99_RS04405 (KHV99_04400)871035..871556-522WP_002916308.1flavodoxin FldB-
KHV99_RS04410 (KHV99_04405)871657..872553+897WP_004144729.1site-specific tyrosine recombinase XerD-
KHV99_RS04415 (KHV99_04410)872576..873289+714WP_002916301.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
KHV99_RS04420 (KHV99_04415)873295..875028+1734WP_004151783.1single-stranded-DNA-specific exonuclease RecJ-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T202321 WP_002916310.1 NZ_CP074541:870618-871028 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T202321 NZ_CP099374:c4400486-4400205 [Citrobacter braakii]
ATGACCTATAACCTGGAGTTTTTAGATGTTGCGCTCAAGGAGTGGCGCAAGCTTTCCCCTGCATTACGTGAACAGTTCAA
AAAGAAACTGGCGGAGCGACTGGAAAATCCCCATGTTCCTGCTGCCCGCCTTTCCGGCAAATTACATCGTTACAAAATCA
AGCTACGCAGTGCTGGGTATCGTCTGGTCTATCAGGTCGAGGACGAGCAGGTTGTCGTTCTTGTGATCGCAGTAGGCAGA
CGTGATGGCGATGAGGTTTATCATCAGGCTAACCGGCGCTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT202321 WP_002916312.1 NZ_CP074541:870371-870637 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202321 NZ_CP099374:c4400724-4400476 [Citrobacter braakii]
ATGCCATTTCATATCCTGACCAAAACCGCTGCCAGCATCACCGACCTGAAACGTAACCCAATGGGGACGGTCAACGCCGG
GGAGGGTGAAGCGGTGGCGATTCTGAACCGCAATGAGCCAGCGTTTTACTGCGTGCCGCCTGCGGTTTATGCGTATCTGC
TGGAGCTGGCAGAAGACGCCGAGCTGAACCGTATCGCCGACGAACGCGAAGGCGGAAAACGAATAAAGGTATCTTTAAAT
GACCTATAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GSW7


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GY41

References