Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5385207..5385832 Replicon chromosome
Accession NZ_CP074539
Organism Klebsiella pneumoniae strain S20_CRE20

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag KHV98_RS26560 Protein ID WP_002882817.1
Coordinates 5385207..5385590 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag KHV98_RS26565 Protein ID WP_004150355.1
Coordinates 5385590..5385832 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV98_RS26545 (KHV98_26470) 5382573..5383475 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
KHV98_RS26550 (KHV98_26475) 5383472..5384107 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
KHV98_RS26555 (KHV98_26480) 5384104..5385033 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
KHV98_RS26560 (KHV98_26485) 5385207..5385590 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
KHV98_RS26565 (KHV98_26490) 5385590..5385832 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
KHV98_RS26570 (KHV98_26495) 5386037..5386954 + 918 WP_002882812.1 alpha/beta hydrolase -
KHV98_RS26575 (KHV98_26500) 5386968..5387909 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
KHV98_RS26580 (KHV98_26505) 5387954..5388391 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
KHV98_RS26585 (KHV98_26510) 5388388..5389248 - 861 WP_002882807.1 virulence factor BrkB family protein -
KHV98_RS26590 (KHV98_26515) 5389242..5389841 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T202316 WP_002882817.1 NZ_CP074539:c5385590-5385207 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T202316 NZ_CP099374:c2887310-2887207 [Citrobacter braakii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT202316 WP_004150355.1 NZ_CP074539:c5385832-5385590 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT202316 NZ_CP099374:2887207-2887345 [Citrobacter braakii]
AAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References