Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2843667..2845255 Replicon chromosome
Accession NZ_CP074539
Organism Klebsiella pneumoniae strain S20_CRE20

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag KHV98_RS13955 Protein ID WP_002904792.1
Coordinates 2843667..2844989 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag KHV98_RS13960 Protein ID WP_002904790.1
Coordinates 2844989..2845255 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV98_RS13940 (KHV98_13900) 2838723..2841224 + 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -
KHV98_RS13945 (KHV98_13905) 2841212..2842216 + 1005 WP_002904798.1 fimbrial protein -
KHV98_RS13950 (KHV98_13910) 2842358..2843650 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
KHV98_RS13955 (KHV98_13915) 2843667..2844989 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
KHV98_RS13960 (KHV98_13920) 2844989..2845255 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KHV98_RS13965 (KHV98_13925) 2845521..2845847 - 327 WP_002904788.1 hydroxyisourate hydrolase -
KHV98_RS13970 (KHV98_13930) 2845844..2846344 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
KHV98_RS13975 (KHV98_13935) 2846322..2847701 - 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
KHV98_RS13980 (KHV98_13940) 2848047..2849201 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
KHV98_RS13985 (KHV98_13945) 2849182..2850105 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T202311 WP_002904792.1 NZ_CP074539:c2844989-2843667 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T202311 NZ_CP099373:4767997-4768377 [Citrobacter portucalensis]
ATGCAAACCTTATCCGCCATCCCGAAGCGGAAGGCACCGTCACGCCCGACGCCCGTTGAAATCTGGCAGCAACTTCTTAC
GTATCTGTTAAAAAGACATTACGGCCTTTCGCTTAGCGACACGCAATTTTCCGATGAGGAGATTATTACGCAATATATTG
ACGCCGGTATCTCACTGTCAGATGCACTCAATTTTCTCGTTGAAAAATCTGAACTGGTGCGGATTGATCGTCCCGGTTTC
TCCATTAAGCATCAGTCCCCTTTTATCGGGGTGATTGATATTCTCCGGGCCAGACGGGCAACGGGTTTGATGCAACGTAA
CGGGTATAAAAGGATCACTCTTCTCATCGCTGGAAATGCAGCTCAGGAGCAACATTCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT202311 WP_002904790.1 NZ_CP074539:c2845255-2844989 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT202311 NZ_CP099373:4767574-4767939 [Citrobacter portucalensis]
TTGTCGAATCAACTACCTCCAGTAAACCATGATGTCTCTGAGCCCTGGTGGGGGCTGAAACCGGGCATCACTCCGTGCTT
TGGCGCACGACTGGTACAGGAAGGCAACCGCCTGCATTATCTGGCTGATCGCGCCAGTATCGCCAGTGTGTTCAGCGATG
CGGATTTACGCCATCTCGATCAGGCATTTCCGGTACTGCTCAAACAGCTGGAATTAATGCTGGTTTCCGGTGAGCTCAAT
CCCCGCCATCAGCACTGTGTCACGTTATATGCAAAAGGACTGACCTGTGAAGCAGATTCCCTCGGATCACATGGCTACAT
TTATACAGCAATTTATCCGACACCAGACGACAGCATAACCCGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References