Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 869595..870252 Replicon chromosome
Accession NZ_CP074539
Organism Klebsiella pneumoniae strain S20_CRE20

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KHV98_RS04390 Protein ID WP_002916310.1
Coordinates 869842..870252 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KHV98_RS04385 Protein ID WP_002916312.1
Coordinates 869595..869861 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV98_RS04360 (KHV98_04355) 864751..866184 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KHV98_RS04365 (KHV98_04360) 866303..867031 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KHV98_RS04370 (KHV98_04365) 867081..867392 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
KHV98_RS04375 (KHV98_04370) 867556..868215 + 660 WP_002916317.1 hemolysin III family protein -
KHV98_RS04380 (KHV98_04375) 868366..869349 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KHV98_RS04385 (KHV98_04380) 869595..869861 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KHV98_RS04390 (KHV98_04385) 869842..870252 + 411 WP_002916310.1 protein YgfX Toxin
KHV98_RS04395 (KHV98_04390) 870259..870780 - 522 WP_002916308.1 flavodoxin FldB -
KHV98_RS04400 (KHV98_04395) 870881..871777 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KHV98_RS04405 (KHV98_04400) 871800..872513 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KHV98_RS04410 (KHV98_04405) 872519..874252 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T202302 WP_002916310.1 NZ_CP074539:869842-870252 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T202302 NZ_CP099373:304301-304669 [Citrobacter portucalensis]
ATGACTCTACAAATTATCTCAGCGGAAGAGATAATCCAGTTTCACGACAGGCTGCTACGTGTAACGCCTGGCGTTGCGGG
CATGCCTGATCCAGGTCGTGCTGAAGCGCTGATGTATCGGGTGTTAAATCAAATTGAATACGAAGGTGTGACCGACGTGT
GGTTGCTTGCCGCAATGCATTTACTGGCTATCTCACGTGGGCATATTTTTAATGATGGTAACAAACGTACCGCTTTGTTT
ATTACGTTACTGTTTTTAAAGCGTAACGGGATAGCTTTGCCTGCAAACCCGGATTTCGTCGCCATGACGGTTGAAGCGGC
TGCGGGCCAGCTGACGCTGGAACAAATAGCCTCCCGCCTGCGTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT202302 WP_002916312.1 NZ_CP074539:869595-869861 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202302 NZ_CP099373:304083-304304 [Citrobacter portucalensis]
ATGCGTACCATGAACTATAGCGAAGCCCGACAAAATCTGGCGGAAGTGCTGGAGAGCGCTGTCACCGGCGTTCCTGTCAC
TATTACACGTCGTGGTCATAAGCCTGCCGTAATCATCAGCGCGGAAGAGTTCGAACGCTATCAGACCGCAAGACTTGATG
ATGAATTTGCCGATATCATGATGGTACATGGTAATGAAATCAGGGAGCTGGCTGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References