Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5029598..5030114 Replicon chromosome
Accession NZ_CP074535
Organism Klebsiella pneumoniae strain S16_CRE16

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KHV97_RS24840 Protein ID WP_002886902.1
Coordinates 5029598..5029882 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KHV97_RS24845 Protein ID WP_002886901.1
Coordinates 5029872..5030114 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV97_RS24815 (KHV97_24755) 5025082..5025345 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KHV97_RS24820 (KHV97_24760) 5025475..5025648 + 174 WP_002886906.1 hypothetical protein -
KHV97_RS24825 (KHV97_24765) 5025651..5026394 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KHV97_RS24830 (KHV97_24770) 5026751..5028889 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KHV97_RS24835 (KHV97_24775) 5029130..5029594 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KHV97_RS24840 (KHV97_24780) 5029598..5029882 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHV97_RS24845 (KHV97_24785) 5029872..5030114 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KHV97_RS24850 (KHV97_24790) 5030192..5032102 - 1911 WP_004152270.1 PRD domain-containing protein -
KHV97_RS24855 (KHV97_24795) 5032125..5033279 - 1155 WP_002886900.1 lactonase family protein -
KHV97_RS24860 (KHV97_24800) 5033345..5034085 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T202294 WP_002886902.1 NZ_CP074535:c5029882-5029598 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T202294 NZ_CP099368:52512-52823 [Citrobacter portucalensis]
ATGCACGTTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAGCGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT202294 WP_002886901.1 NZ_CP074535:c5030114-5029872 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT202294 NZ_CP099368:52820-53239 [Citrobacter portucalensis]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACTTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCGGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTCCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCATTAACACTGGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCAA
GCTCATTCATGGACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References