Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2860127..2861715 Replicon chromosome
Accession NZ_CP074535
Organism Klebsiella pneumoniae strain S16_CRE16

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag KHV97_RS14015 Protein ID WP_002904792.1
Coordinates 2860127..2861449 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag KHV97_RS14020 Protein ID WP_002904790.1
Coordinates 2861449..2861715 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV97_RS14000 (KHV97_13965) 2855183..2857684 + 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -
KHV97_RS14005 (KHV97_13970) 2857672..2858676 + 1005 WP_002904798.1 fimbrial protein -
KHV97_RS14010 (KHV97_13975) 2858818..2860110 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
KHV97_RS14015 (KHV97_13980) 2860127..2861449 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
KHV97_RS14020 (KHV97_13985) 2861449..2861715 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KHV97_RS14025 (KHV97_13990) 2861981..2862307 - 327 WP_002904788.1 hydroxyisourate hydrolase -
KHV97_RS14030 (KHV97_13995) 2862304..2862804 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
KHV97_RS14035 (KHV97_14000) 2862782..2864161 - 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
KHV97_RS14040 (KHV97_14005) 2864507..2865661 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
KHV97_RS14045 (KHV97_14010) 2865642..2866565 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T202291 WP_002904792.1 NZ_CP074535:c2861449-2860127 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T202291 NZ_CP099367:2654009-2654491 [Citrobacter portucalensis]
GTGGGATTTGTAACCGCACCTGAGCCTCTAACTCACATTCATCGATTGGCGGAATTTGTCAGCGGAGAAATTATTCTCGA
TGATTGGTTAAAGCAAAAAGGGCTAAAAAATCAGGCTCTCGGCGCAGCCAGGACGTTTGTTGTCTGCAAAACAGACACGC
GACAAGTCGCTGGCTTTTATTCACTGGCCACAGGTAGCGTCAACCACACAGAAGCAACAGGCAATCTTCGGCGTAACATG
CCAGATCCAATCCCCGTAATTATCCTTGCCAGATTGGCCGTAGATCTTTCTGTTCGTGGAAAAGGGTTAGGGGCCGATCT
GCTTCACGATGCGGTACTGCGGTGTTACAAAGTGGCAGAAAATATTGGCGTGCGTGCCGTTATGGTACATGCGCTCACAG
ACGAAGCTAAACGTTTTTATCTTCACCACGGATTCAAAGCATCTCAACTGCAGGAACGCACTCTGTTCCTCAGGCTTTCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT202291 WP_002904790.1 NZ_CP074535:c2861715-2861449 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT202291 NZ_CP099367:2653755-2654021 [Citrobacter portucalensis]
ATGAAATCAGATGTCCAGCTCAACCTTAGAGCTAAAGAATCCCAACGCGCGCTTATTGATGCGGCCGCAGAGATTCTACA
TAAATCGCGTACAGACTTTATTCTGGAAATGGCCTGCCAGGCGGCAGAGAACGTTATTCTCGATCGCCGAGTGTTTAATT
TTAATGATGAACAATACGCTGAGTTTATCGAGATGCTTGATGCTCCGGTTGCCGAAGATCCCGCTATCAGGAAGCTACTG
GCAAGGAAACCACAGTGGGATTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References