Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 869594..870251 Replicon chromosome
Accession NZ_CP074535
Organism Klebsiella pneumoniae strain S16_CRE16

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KHV97_RS04390 Protein ID WP_002916310.1
Coordinates 869841..870251 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KHV97_RS04385 Protein ID WP_002916312.1
Coordinates 869594..869860 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV97_RS04360 (KHV97_04355) 864750..866183 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KHV97_RS04365 (KHV97_04360) 866302..867030 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KHV97_RS04370 (KHV97_04365) 867080..867391 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
KHV97_RS04375 (KHV97_04370) 867555..868214 + 660 WP_002916317.1 hemolysin III family protein -
KHV97_RS04380 (KHV97_04375) 868365..869348 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KHV97_RS04385 (KHV97_04380) 869594..869860 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KHV97_RS04390 (KHV97_04385) 869841..870251 + 411 WP_002916310.1 protein YgfX Toxin
KHV97_RS04395 (KHV97_04390) 870258..870779 - 522 WP_002916308.1 flavodoxin FldB -
KHV97_RS04400 (KHV97_04395) 870880..871776 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KHV97_RS04405 (KHV97_04400) 871799..872512 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KHV97_RS04410 (KHV97_04405) 872518..874251 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T202282 WP_002916310.1 NZ_CP074535:869841-870251 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T202282 NZ_CP099366:c1219166-1218948 [Citrobacter braakii]
ATGTCCGATAAACCATTAACTAAAACTGATTATTTGATGCGCCTGCGACGTTGTCAGACAATTGACACACTTGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCACCGCCTTGCTGAAT
TGACTATGAATAAGCTCTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT202282 WP_002916312.1 NZ_CP074535:869594-869860 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202282 NZ_CP099366:c1219568-1219194 [Citrobacter braakii]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCCACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGGTCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References