Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 40954..41714 | Replicon | plasmid pCRE14_1 |
Accession | NZ_CP074529 | ||
Organism | Klebsiella pneumoniae strain S14_CRE14 |
Toxin (Protein)
Gene name | tacT | Uniprot ID | - |
Locus tag | KHV96_RS26770 | Protein ID | WP_064177585.1 |
Coordinates | 41208..41714 (+) | Length | 169 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | L7SZ29 |
Locus tag | KHV96_RS26765 | Protein ID | WP_003026799.1 |
Coordinates | 40954..41220 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KHV96_RS26720 | 36440..36602 | - | 163 | Protein_35 | type II toxin-antitoxin system RelE/ParE family toxin | - |
KHV96_RS26725 (KHV96_26635) | 36724..36903 | - | 180 | WP_065520248.1 | type II toxin-antitoxin system ParD family antitoxin | - |
KHV96_RS26730 (KHV96_26640) | 37216..37461 | + | 246 | WP_064177598.1 | hypothetical protein | - |
KHV96_RS26735 (KHV96_26645) | 37466..38038 | + | 573 | WP_064177597.1 | hypothetical protein | - |
KHV96_RS26740 (KHV96_26650) | 38069..38563 | + | 495 | WP_064177596.1 | hypothetical protein | - |
KHV96_RS26745 (KHV96_26655) | 38624..38827 | + | 204 | WP_004213596.1 | HHA domain-containing protein | - |
KHV96_RS26750 (KHV96_26660) | 38841..39071 | + | 231 | WP_049118762.1 | hypothetical protein | - |
KHV96_RS26760 (KHV96_26670) | 40524..40778 | + | 255 | WP_044246670.1 | hypothetical protein | - |
KHV96_RS26765 (KHV96_26675) | 40954..41220 | + | 267 | WP_003026799.1 | DUF1778 domain-containing protein | Antitoxin |
KHV96_RS26770 (KHV96_26680) | 41208..41714 | + | 507 | WP_064177585.1 | GNAT family N-acetyltransferase | Toxin |
KHV96_RS26775 (KHV96_26685) | 41897..43243 | + | 1347 | WP_077255522.1 | ISNCY family transposase | - |
KHV96_RS26780 (KHV96_26690) | 43292..43690 | + | 399 | WP_032422684.1 | helix-turn-helix domain-containing protein | - |
KHV96_RS26785 (KHV96_26695) | 43870..44901 | + | 1032 | WP_046092923.1 | IS630-like element ISEc33 family transposase | - |
KHV96_RS26790 | 44993..45103 | - | 111 | Protein_49 | IS3 family transposase | - |
KHV96_RS26795 | 45119..45268 | - | 150 | Protein_50 | transposase | - |
KHV96_RS26800 (KHV96_26705) | 45378..46317 | + | 940 | Protein_51 | ISNCY family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | - | 1..158574 | 158574 | |
- | inside | IScluster/Tn | - | - | 33892..46335 | 12443 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 169 a.a. Molecular weight: 18119.99 Da Isoelectric Point: 9.6090
>T202276 WP_064177585.1 NZ_CP074529:41208-41714 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLRQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP
RLIIGVGK
VGCITAPEPLSSAHQLAEFVSGETVLDEWLRQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP
RLIIGVGK
Download Length: 507 bp
>T202276 NZ_CP099364:c4719799-4719488 [Citrobacter braakii]
ATGCTATTCATAGAAACGGAAATATTCACTGAAGACGTCAAAAAATTACTGGATGATGATGAATACCGTAGATTACAGAT
ATTCCTTGCGATTCAGCCCGATTGTGGCGATCTAATACAAGAAACGGGGGGCCTGAGAAAGGTTCGCTGGAGAGCGCGAG
GGAAAGGAAAACGTGGTGGTGTGAGGATTATCTATTTTCATCAAATCAGGAAATCACAAATTCGATTGTTGCTGATTTAT
CAGAAAGGGATTAAGGATGATCTGACTCCGCAAGAAAAAGTACTGCTGCGTATGTTGAATGAGAGGTGGTAA
ATGCTATTCATAGAAACGGAAATATTCACTGAAGACGTCAAAAAATTACTGGATGATGATGAATACCGTAGATTACAGAT
ATTCCTTGCGATTCAGCCCGATTGTGGCGATCTAATACAAGAAACGGGGGGCCTGAGAAAGGTTCGCTGGAGAGCGCGAG
GGAAAGGAAAACGTGGTGGTGTGAGGATTATCTATTTTCATCAAATCAGGAAATCACAAATTCGATTGTTGCTGATTTAT
CAGAAAGGGATTAAGGATGATCTGACTCCGCAAGAAAAAGTACTGCTGCGTATGTTGAATGAGAGGTGGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10147.59 Da Isoelectric Point: 4.5256
>AT202276 WP_003026799.1 NZ_CP074529:40954-41220 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV
Download Length: 267 bp
>AT202276 NZ_CP099364:c4719487-4719200 [Citrobacter braakii]
ATGGATAAGGCACTATTTGAGCGACTAACTCAAAGTATGGTTCAGATGAATGAGATCGCTGAAGGAACACGGCAACCTTC
CCGTACTTTTCATATTGATGCCATGAAAATAAAGGAAATCCGCCTGTCTTCAGGATTATCACAGACTCGTTTCGCAGATT
TGATATCGGTAAGCGTGGATACGTTGCGCAATTGGGAGCAGGGGCGTCGTTCACCGACTGGTCCAGCAAAAGCGTTGTTA
CGTGCCATTGCCAATGATCCAAAACATGTCATTCAGGCGCTAAGATAA
ATGGATAAGGCACTATTTGAGCGACTAACTCAAAGTATGGTTCAGATGAATGAGATCGCTGAAGGAACACGGCAACCTTC
CCGTACTTTTCATATTGATGCCATGAAAATAAAGGAAATCCGCCTGTCTTCAGGATTATCACAGACTCGTTTCGCAGATT
TGATATCGGTAAGCGTGGATACGTTGCGCAATTGGGAGCAGGGGCGTCGTTCACCGACTGGTCCAGCAAAAGCGTTGTTA
CGTGCCATTGCCAATGATCCAAAACATGTCATTCAGGCGCTAAGATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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