Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4898901..4899417 Replicon chromosome
Accession NZ_CP074528
Organism Klebsiella pneumoniae strain S14_CRE14

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KHV96_RS23940 Protein ID WP_004178374.1
Coordinates 4898901..4899185 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KHV96_RS23945 Protein ID WP_002886901.1
Coordinates 4899175..4899417 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV96_RS23915 (4894385) 4894385..4894648 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
KHV96_RS23920 (4894778) 4894778..4894951 + 174 WP_032408826.1 hypothetical protein -
KHV96_RS23925 (4894954) 4894954..4895697 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KHV96_RS23930 (4896054) 4896054..4898192 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KHV96_RS23935 (4898433) 4898433..4898897 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KHV96_RS23940 (4898901) 4898901..4899185 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHV96_RS23945 (4899175) 4899175..4899417 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KHV96_RS23950 (4899495) 4899495..4901405 - 1911 WP_004178373.1 PRD domain-containing protein -
KHV96_RS23955 (4901428) 4901428..4902582 - 1155 WP_004178372.1 lactonase family protein -
KHV96_RS23960 (4902649) 4902649..4903389 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T202272 WP_004178374.1 NZ_CP074528:c4899185-4898901 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T202272 NZ_CP099364:c2818909-2818806 [Citrobacter braakii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT202272 WP_002886901.1 NZ_CP074528:c4899417-4899175 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT202272 NZ_CP099364:2818801-2818944 [Citrobacter braakii]
CACATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References