Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5079195..5080876 Replicon chromosome
Accession NZ_CP074523
Organism Klebsiella pneumoniae strain S12_CRE12

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag KHV95_RS25330 Protein ID WP_002885155.1
Coordinates 5079195..5080112 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag KHV95_RS25335 Protein ID WP_004151732.1
Coordinates 5080118..5080876 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV95_RS25310 (KHV95_25245) 5074501..5076021 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
KHV95_RS25315 (KHV95_25250) 5076018..5077016 + 999 WP_002885172.1 ribose ABC transporter permease -
KHV95_RS25320 (KHV95_25255) 5077047..5077988 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
KHV95_RS25325 (KHV95_25260) 5078063..5079070 + 1008 WP_004151731.1 carbohydrate kinase family protein -
KHV95_RS25330 (KHV95_25265) 5079195..5080112 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
KHV95_RS25335 (KHV95_25270) 5080118..5080876 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
KHV95_RS25340 (KHV95_25275) 5080962..5081690 - 729 WP_002885152.1 response regulator transcription factor -
KHV95_RS25345 (KHV95_25280) 5081963..5084110 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
KHV95_RS25350 (KHV95_25285) 5084340..5085026 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T202253 WP_002885155.1 NZ_CP074523:c5080112-5079195 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T202253 NZ_CP099358:1303981-1304379 [Escherichia fergusonii]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCCGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATTTATGGGGCAGAAAAAAGCCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGCTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCCGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCTGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT202253 WP_004151732.1 NZ_CP074523:c5080876-5080118 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT202253 NZ_CP099358:1303754-1303981 [Escherichia fergusonii]
ATGGAAACCACTGTATTTTTAAGTAATCGCAGTCAGGCTGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGACGGCG
AAAATGTGAGTGCAGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References