Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4919163..4919679 Replicon chromosome
Accession NZ_CP074523
Organism Klebsiella pneumoniae strain S12_CRE12

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KHV95_RS24510 Protein ID WP_002886902.1
Coordinates 4919163..4919447 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KHV95_RS24515 Protein ID WP_002886901.1
Coordinates 4919437..4919679 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV95_RS24485 (KHV95_24420) 4914647..4914910 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KHV95_RS24490 (KHV95_24425) 4915040..4915213 + 174 WP_002886906.1 hypothetical protein -
KHV95_RS24495 (KHV95_24430) 4915216..4915959 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KHV95_RS24500 (KHV95_24435) 4916316..4918454 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KHV95_RS24505 (KHV95_24440) 4918695..4919159 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KHV95_RS24510 (KHV95_24445) 4919163..4919447 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHV95_RS24515 (KHV95_24450) 4919437..4919679 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KHV95_RS24520 (KHV95_24455) 4919757..4921667 - 1911 WP_270104185.1 PRD domain-containing protein -
KHV95_RS24525 (KHV95_24460) 4921690..4922844 - 1155 WP_002886900.1 lactonase family protein -
KHV95_RS24530 (KHV95_24465) 4922910..4923650 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T202252 WP_002886902.1 NZ_CP074523:c4919447-4919163 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T202252 NZ_CP099358:1104761-1105063 [Escherichia fergusonii]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCACTCAACGCCACATAGAAA
GATTCCTGCTGAAATCCATACCACATTATCAAGAAAATTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTATTTAGATCCACACAACTACTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT202252 WP_002886901.1 NZ_CP074523:c4919679-4919437 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT202252 NZ_CP099358:1105099-1105440 [Escherichia fergusonii]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAGCCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACAACTG
AAATGGCGTTTCGTCTGGCTAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCGGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACACAAGAAGAATTGGGACGGATTGAAACAGTGGCTGACTATTTGGCTCGCCGTGAAGA
GCGTGCAAAGAATGTTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References