Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4206095..4206714 Replicon chromosome
Accession NZ_CP074523
Organism Klebsiella pneumoniae strain S12_CRE12

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KHV95_RS21100 Protein ID WP_002892050.1
Coordinates 4206496..4206714 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KHV95_RS21095 Protein ID WP_002892066.1
Coordinates 4206095..4206469 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV95_RS21085 (KHV95_21035) 4201247..4202440 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KHV95_RS21090 (KHV95_21040) 4202463..4205609 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KHV95_RS21095 (KHV95_21045) 4206095..4206469 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KHV95_RS21100 (KHV95_21050) 4206496..4206714 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KHV95_RS21105 (KHV95_21055) 4206873..4207439 + 567 WP_002892030.1 maltose O-acetyltransferase -
KHV95_RS21110 (KHV95_21060) 4207411..4207551 - 141 WP_004147370.1 hypothetical protein -
KHV95_RS21115 (KHV95_21065) 4207572..4208042 + 471 WP_002892026.1 YlaC family protein -
KHV95_RS21120 (KHV95_21070) 4208017..4209468 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KHV95_RS21125 (KHV95_21075) 4209569..4210267 + 699 WP_002892021.1 GNAT family protein -
KHV95_RS21130 (KHV95_21080) 4210264..4210404 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KHV95_RS21135 (KHV95_21085) 4210404..4210667 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T202250 WP_002892050.1 NZ_CP074523:4206496-4206714 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T202250 NZ_CP099358:c569063-568911 [Escherichia fergusonii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT202250 WP_002892066.1 NZ_CP074523:4206095-4206469 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT202250 NZ_CP099358:569112-569169 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References