Detailed information of TA system TA202232

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4762359..4764040
• Replicon: chromosome
• Accession: NZ_CP074519
• Organism: Klebsiella pneumoniae strain S10_CRE10

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: KHV94_RS23385
• Protein ID: WP_270104234.1
• Coordinates: 4762359..4763276 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: KHV94_RS23390
• Protein ID: WP_004177809.1
• Coordinates: 4763282..4764040 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KHV94_RS23365 (4757665)	4757665..4759185	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
KHV94_RS23370 (4759182)	4759182..4760180	+	999	WP_012737175.1	ribose ABC transporter permease	-
KHV94_RS23375 (4760211)	4760211..4761152	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
KHV94_RS23380 (4761227)	4761227..4762234	+	1008	WP_023302355.1	carbohydrate kinase family protein	-
KHV94_RS23385 (4762359)	4762359..4763276	-	918	WP_270104234.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KHV94_RS23390 (4763282)	4763282..4764040	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KHV94_RS23395 (4764126)	4764126..4764854	-	729	WP_002885152.1	response regulator transcription factor	-
KHV94_RS23400 (4765127)	4765127..4767274	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
KHV94_RS23405 (4767504)	4767504..4768190	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34631.04 Da
• Isoelectric Point: 5.2461

>T202232 WP_270104234.1 NZ_CP074519:c4763276-4762359 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEQEVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T202232 NZ_CP099349:4035705-4036007 [Escherichia fergusonii]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCACTCAACGCCACATAGAAA
GATTCCTGCTGAAATCCATACCACATTATCAAGAAAATTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTATTTAGATCCACACAACTACTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT202232 WP_004177809.1 NZ_CP074519:c4764040-4763282 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT202232 NZ_CP099349:4036043-4036384 [Escherichia fergusonii]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAGCCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACAACTG
AAATGGCGTTTCGTCTGGCTAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCGGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACACAAGAAGAATTGGGACGGATTGAAACAGTGGCTGACTATTTGGCTCGCCGTGAAGA
GCGTGCAAAGAATGTTGCGTAA

Structures

Antitoxin

• AlphaFold DB: A6TH05