Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4602891..4603407 Replicon chromosome
Accession NZ_CP074519
Organism Klebsiella pneumoniae strain S10_CRE10

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KHV94_RS22585 Protein ID WP_002886902.1
Coordinates 4602891..4603175 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KHV94_RS22590 Protein ID WP_002886901.1
Coordinates 4603165..4603407 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV94_RS22560 (4598307) 4598307..4598570 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
KHV94_RS22565 (4598700) 4598700..4598873 + 174 WP_032410138.1 hypothetical protein -
KHV94_RS22570 (4598876) 4598876..4599619 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
KHV94_RS22575 (4599976) 4599976..4602114 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KHV94_RS22580 (4602423) 4602423..4602887 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KHV94_RS22585 (4602891) 4602891..4603175 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHV94_RS22590 (4603165) 4603165..4603407 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KHV94_RS22595 (4603485) 4603485..4605395 - 1911 WP_009486549.1 PRD domain-containing protein -
KHV94_RS22600 (4605418) 4605418..4606572 - 1155 WP_023302389.1 lactonase family protein -
KHV94_RS22605 (4606639) 4606639..4607379 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T202231 WP_002886902.1 NZ_CP074519:c4603175-4602891 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T202231 NZ_CP099349:3826573-3826725 [Escherichia fergusonii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT202231 WP_002886901.1 NZ_CP074519:c4603407-4603165 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT202231 NZ_CP099349:c3826531-3826479 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References