Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3894056..3894675 Replicon chromosome
Accession NZ_CP074519
Organism Klebsiella pneumoniae strain S10_CRE10

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KHV94_RS19190 Protein ID WP_002892050.1
Coordinates 3894457..3894675 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KHV94_RS19185 Protein ID WP_002892066.1
Coordinates 3894056..3894430 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV94_RS19175 (3889208) 3889208..3890401 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KHV94_RS19180 (3890424) 3890424..3893570 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KHV94_RS19185 (3894056) 3894056..3894430 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KHV94_RS19190 (3894457) 3894457..3894675 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KHV94_RS19195 (3894834) 3894834..3895400 + 567 WP_002892030.1 maltose O-acetyltransferase -
KHV94_RS19200 (3895372) 3895372..3895512 - 141 WP_004147370.1 hypothetical protein -
KHV94_RS19205 (3895533) 3895533..3896003 + 471 WP_002892026.1 YlaC family protein -
KHV94_RS19210 (3895978) 3895978..3897429 - 1452 WP_023302231.1 PLP-dependent aminotransferase family protein -
KHV94_RS19215 (3897530) 3897530..3898228 + 699 WP_002892021.1 GNAT family protein -
KHV94_RS19220 (3898225) 3898225..3898365 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KHV94_RS19225 (3898365) 3898365..3898628 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T202229 WP_002892050.1 NZ_CP074519:3894457-3894675 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T202229 NZ_CP099349:c3439091-3438627 [Escherichia fergusonii]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT202229 WP_002892066.1 NZ_CP074519:3894056-3894430 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT202229 NZ_CP099349:c3439426-3439091 [Escherichia fergusonii]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGGCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAGGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References