Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 789938..790595 Replicon chromosome
Accession NZ_CP074519
Organism Klebsiella pneumoniae strain S10_CRE10

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KHV94_RS03930 Protein ID WP_002916310.1
Coordinates 790185..790595 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KHV94_RS03925 Protein ID WP_002916312.1
Coordinates 789938..790204 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV94_RS03900 (785094) 785094..786527 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KHV94_RS03905 (786646) 786646..787374 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KHV94_RS03910 (787424) 787424..787735 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KHV94_RS03915 (787899) 787899..788558 + 660 WP_002916317.1 hemolysin III family protein -
KHV94_RS03920 (788709) 788709..789692 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
KHV94_RS03925 (789938) 789938..790204 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KHV94_RS03930 (790185) 790185..790595 + 411 WP_002916310.1 protein YgfX Toxin
KHV94_RS03935 (790602) 790602..791123 - 522 WP_004144730.1 flavodoxin FldB -
KHV94_RS03940 (791224) 791224..792120 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KHV94_RS03945 (792143) 792143..792856 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KHV94_RS03950 (792862) 792862..794595 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T202219 WP_002916310.1 NZ_CP074519:790185-790595 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T202219 NZ_CP099349:c1058669-1058415 [Escherichia fergusonii]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACTCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT202219 WP_002916312.1 NZ_CP074519:789938-790204 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202219 NZ_CP099349:c1058917-1058666 [Escherichia fergusonii]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAACGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAAGAGACGGCTTATC
TATTGCGTTCCCCCGCTAATGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References