Detailed information of TA system TA202204

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-ArgA
• Location: 921135..921954
• Replicon: chromosome
• Accession: NZ_CP074449
• Organism: Klebsiella michiganensis strain S4_CRE4

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: KHV91_RS04265
• Protein ID: WP_004110819.1
• Coordinates: 921135..921392 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: KHV91_RS04270
• Protein ID: WP_270104658.1
• Coordinates: 921403..921954 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KHV91_RS04250 (KHV91_04245)	916802..917578	-	777	WP_004847986.1	Uxu operon transcriptional regulator	-
KHV91_RS04255 (KHV91_04250)	917717..919201	-	1485	WP_064405208.1	fructuronate reductase	-
KHV91_RS04260 (KHV91_04255)	919275..920459	-	1185	WP_014228054.1	mannonate dehydratase	-
KHV91_RS04265 (KHV91_04260)	921135..921392	+	258	WP_004110819.1	YjhX family toxin	Toxin
KHV91_RS04270 (KHV91_04265)	921403..921954	+	552	WP_270104658.1	N-acetyltransferase	Antitoxin
KHV91_RS04275	922068..922430	+	363	Protein_834	class I SAM-dependent methyltransferase	-
KHV91_RS04280	922854..923600	+	747	WP_224244006.1	class I SAM-dependent methyltransferase	-
KHV91_RS04285 (KHV91_04275)	923817..924704	-	888	WP_064405204.1	DMT family transporter	-
KHV91_RS04290 (KHV91_04280)	924824..925732	+	909	WP_064405202.1	transcriptional regulator GcvA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (22-130)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T202204 WP_004110819.1 NZ_CP074449:921135-921392 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T202204 NZ_CP099344:c668776-668600 [Escherichia marmotae]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCAATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20004.83 Da
• Isoelectric Point: 6.4897

>AT202204 WP_270104658.1 NZ_CP074449:921403-921954 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGELIRHGIEQLKAMGSQAVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPAVHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT202204 NZ_CP099344:c668554-668138 [Escherichia marmotae]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCCGAAGCGTTGAC
GCAGGGAGAAACGGTCGCTGAAGCGATGGAAGCAGCAAAAGATGCCTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAACTCATCCCGTTACCTTCGCCATTGAATAACAACGATCACTTTATTGAAGTACCTTTAAGTGTTGCTTCTAAGGTA
TTGCTGCTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2