Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3714144..3714801 Replicon chromosome
Accession NZ_CP074448
Organism Enterobacter asburiae strain S3_CRE3

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag KHV90_RS17540 Protein ID WP_021242050.1
Coordinates 3714144..3714554 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag KHV90_RS17545 Protein ID WP_010435322.1
Coordinates 3714535..3714801 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV90_RS17520 (KHV90_17470) 3710137..3711870 - 1734 WP_039262981.1 single-stranded-DNA-specific exonuclease RecJ -
KHV90_RS17525 (KHV90_17475) 3711876..3712589 - 714 WP_047060452.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KHV90_RS17530 (KHV90_17480) 3712618..3713514 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
KHV90_RS17535 (KHV90_17485) 3713616..3714137 + 522 WP_039262979.1 flavodoxin FldB -
KHV90_RS17540 (KHV90_17490) 3714144..3714554 - 411 WP_021242050.1 protein YgfX Toxin
KHV90_RS17545 (KHV90_17495) 3714535..3714801 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
KHV90_RS17550 (KHV90_17500) 3715096..3716076 + 981 WP_029739202.1 tRNA-modifying protein YgfZ -
KHV90_RS17555 (KHV90_17505) 3716151..3716810 - 660 WP_033146591.1 hemolysin III family protein -
KHV90_RS17560 (KHV90_17510) 3716976..3717287 - 312 WP_048980550.1 N(4)-acetylcytidine aminohydrolase -
KHV90_RS17565 (KHV90_17515) 3717339..3718070 + 732 WP_032660101.1 MurR/RpiR family transcriptional regulator -
KHV90_RS17570 (KHV90_17520) 3718187..3719620 + 1434 WP_048980547.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T202200 WP_021242050.1 NZ_CP074448:c3714554-3714144 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T202200 NZ_CP099342:23279-23584 [Escherichia fergusonii]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGTCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGTGATGAAAGCTGGCGCATGATGACCTCCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGGGAAAATGACATCAAAAACGCCATTAACCTGATGTTTTGGGGAATATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT202200 WP_010435322.1 NZ_CP074448:c3714801-3714535 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202200 NZ_CP099342:23059-23277 [Escherichia fergusonii]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References