Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 3454737..3455333 Replicon chromosome
Accession NZ_CP074448
Organism Enterobacter asburiae strain S3_CRE3

Toxin (Protein)


Gene name PumA Uniprot ID A0A808I9K6
Locus tag KHV90_RS16355 Protein ID WP_048979397.1
Coordinates 3454737..3455039 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A808IFF3
Locus tag KHV90_RS16360 Protein ID WP_033144375.1
Coordinates 3455046..3455333 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV90_RS16335 (KHV90_16290) 3450956..3452305 + 1350 WP_023309996.1 lysine-sensitive aspartokinase 3 -
KHV90_RS16340 (KHV90_16295) 3452399..3453343 + 945 WP_048979398.1 ketopantoate/pantoate/pantothenate transporter PanS -
KHV90_RS16345 (KHV90_16300) 3453394..3453666 + 273 WP_023309994.1 DUF3811 domain-containing protein -
KHV90_RS16350 (KHV90_16305) 3453667..3454539 - 873 WP_033144377.1 23S rRNA pseudouridine(2604) synthase RluF -
KHV90_RS16355 (KHV90_16310) 3454737..3455039 + 303 WP_048979397.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHV90_RS16360 (KHV90_16315) 3455046..3455333 + 288 WP_033144375.1 putative addiction module antidote protein Antitoxin
KHV90_RS16365 (KHV90_16320) 3455330..3456961 - 1632 WP_048979396.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11401.17 Da        Isoelectric Point: 9.6038

>T202199 WP_048979397.1 NZ_CP074448:3454737-3455039 [Enterobacter asburiae]
MKEIVQTESFQRWEQNLKDRRAKTIIASRLFRLANGLAGDIKPVGEGISELRIHYGPGYRLYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T202199 NZ_CP099341:4806-5180 [Escherichia fergusonii]
ATGATATTAGTAGATACATCTGTATGGGTTGATCATTTTAAAAATAAAAATGATACATTGATTCAACTATTGCAGTCAGA
CTTTGTCCTTATGCACCCAATGATCTTGGCAGAAATAGCATGCGGTACTCCGCCAGCCCCCAGACAACGAACATTAAGCG
ATTTGGACTTATTACCGAAAAGTCATCAGGCCACAATTACTGAAGTTTTAGCCTTCATCGAAAATGAAAGATTATTTGGC
TTAGGTTGTGGTCTGGTTGATATAACATTATTAGCGTCAACCAAGATTACTCCCAGTGCGAAAATATGGACGTTAGATAA
ACGTTTATCGCAACTAGCAAAACGCCTGAACCTAGAATATCAACCTGTACATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10111.59 Da        Isoelectric Point: 6.4596

>AT202199 WP_033144375.1 NZ_CP074448:3455046-3455333 [Enterobacter asburiae]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKHAGD

Download         Length: 288 bp

>AT202199 NZ_CP099341:4606-4809 [Escherichia fergusonii]
ATGAGAACTACTGTAACAATCGACGATGTTCTGTACGCGCAAGCACTGGAAATGGCAGATCCCGGAATGGATAAATCAGA
TATTTTCCGTGAAGCAGTGAAAACATTTATCCGTGTGCAGGCTGCGAAACGCCTAGCTTCACTCGGAGGAACAACTCCAG
ATATGGAAATAACACCACGCAGGCGTGAGGACGTAGCTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808I9K6

Antitoxin

Source ID Structure
AlphaFold DB A0A808IFF3

References