202185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4625465..4625981 Replicon chromosome
Accession NZ_CP074446
Organism Klebsiella aerogenes strain S2_CRE2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KHV89_RS21665 Protein ID WP_046883307.1
Coordinates 4625465..4625749 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KHV89_RS21670 Protein ID WP_002886901.1
Coordinates 4625739..4625981 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV89_RS21645 (4620880) 4620880..4621143 - 264 WP_015368564.1 PTS sugar transporter subunit IIB -
KHV89_RS21650 (4621450) 4621450..4622193 + 744 WP_049052638.1 MurR/RpiR family transcriptional regulator -
KHV89_RS21655 (4622551) 4622551..4624689 + 2139 WP_015368566.1 anaerobic ribonucleoside-triphosphate reductase -
KHV89_RS21660 (4624997) 4624997..4625461 + 465 WP_045386772.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KHV89_RS21665 (4625465) 4625465..4625749 - 285 WP_046883307.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHV89_RS21670 (4625739) 4625739..4625981 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KHV89_RS21675 (4626059) 4626059..4627969 - 1911 WP_042894240.1 PRD domain-containing protein -
KHV89_RS21680 (4627992) 4627992..4629143 - 1152 WP_015368569.1 lactonase family protein -
KHV89_RS21685 (4629209) 4629209..4629949 - 741 WP_015368570.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11179.07 Da        Isoelectric Point: 10.4951

>T202185 WP_046883307.1 NZ_CP074446:c4625749-4625465 [Klebsiella aerogenes]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRMESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYRQANKRL

Download         Length: 285 bp

>T202185 NZ_CP099338:1919288-1919391 [Escherichia fergusonii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT202185 WP_002886901.1 NZ_CP074446:c4625981-4625739 [Klebsiella aerogenes]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT202185 NZ_CP099338:c1919429-1919161 [Escherichia fergusonii]
AAAGTCAGCGAATGGAATATTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References