Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4533901..4534583 Replicon chromosome
Accession NZ_CP074446
Organism Klebsiella aerogenes strain S2_CRE2

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag KHV89_RS21275 Protein ID WP_064360218.1
Coordinates 4533901..4534221 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag KHV89_RS21280 Protein ID WP_270099841.1
Coordinates 4534242..4534583 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV89_RS21260 (4530846) 4530846..4531604 + 759 WP_227540463.1 DNA/RNA non-specific endonuclease -
KHV89_RS21265 (4531720) 4531720..4532064 + 345 WP_047041142.1 DUF1294 domain-containing protein -
KHV89_RS21270 (4532661) 4532661..4533794 + 1134 WP_064360217.1 hypothetical protein -
KHV89_RS21275 (4533901) 4533901..4534221 - 321 WP_064360218.1 TA system toxin CbtA family protein Toxin
KHV89_RS21280 (4534242) 4534242..4534583 - 342 WP_270099841.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KHV89_RS21285 (4534594) 4534594..4535133 - 540 WP_064360220.1 DNA repair protein RadC -
KHV89_RS21290 (4535146) 4535146..4535586 - 441 WP_224257213.1 antirestriction protein -
KHV89_RS21295 (4535617) 4535617..4536438 - 822 WP_064360222.1 DUF932 domain-containing protein -
KHV89_RS21300 (4536558) 4536558..4537031 - 474 WP_064360223.1 hypothetical protein -
KHV89_RS21305 (4537103) 4537103..4537555 - 453 WP_000734321.1 hypothetical protein -
KHV89_RS21310 (4537591) 4537591..4538307 - 717 WP_270099846.1 WYL domain-containing protein -
KHV89_RS21315 (4538551) 4538551..4539426 - 876 WP_270099848.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-102)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12024.91 Da        Isoelectric Point: 7.1633

>T202184 WP_064360218.1 NZ_CP074446:c4534221-4533901 [Klebsiella aerogenes]
MKTLPAINPQAATLCLSPVAVWQKLLARLLEQHYGLTLNDTPFSDETVILEHIYAGISLADAVNFLVEKYELVRIDRRGF
NWREQSPYLQVVDILRVRQAIGSSSK

Download         Length: 321 bp

>T202184 NZ_CP099338:1222057-1222359 [Escherichia fergusonii]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCACTCAACGCCACATAGAAA
GATTCCTGCTGAAATCCATACCACATTATCAAGAAAATTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTATTTAGATCCACACAACTACTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12873.41 Da        Isoelectric Point: 5.9600

>AT202184 WP_270099841.1 NZ_CP074446:c4534583-4534242 [Klebsiella aerogenes]
MKSTDSENDSFLQWGLNRNVTPCFGARLVQEGNRLHYLVDRASITGEFSNAESLKLDEVFPHFISKMESMLTTGELNPRH
AHCFTLYHNGFTCEADTLGSYGYVYIAIYPTQR

Download         Length: 342 bp

>AT202184 NZ_CP099338:1222395-1222736 [Escherichia fergusonii]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAGCCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACAACTG
AAATGGCGTTTCGTCTGGCTAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCGGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACACAAGAAGAATTGGGACGGATTGAAACAGTGGCTGACTATTTGGCTCGCCGTGAAGA
GCGTGCAAAGAAGGTTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References