202183

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4521158..4521968 Replicon chromosome
Accession NZ_CP074446
Organism Klebsiella aerogenes strain S2_CRE2

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag KHV89_RS21220 Protein ID WP_032715534.1
Coordinates 4521158..4521691 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag KHV89_RS21225 Protein ID WP_002887278.1
Coordinates 4521702..4521968 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV89_RS21215 (4519990) 4519990..4521111 + 1122 WP_015704249.1 cupin domain-containing protein -
KHV89_RS21220 (4521158) 4521158..4521691 - 534 WP_032715534.1 type II toxin-antitoxin system toxin KacT Toxin
KHV89_RS21225 (4521702) 4521702..4521968 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
KHV89_RS21230 (4522047) 4522047..4523504 - 1458 WP_103826225.1 Cu(+)/Ag(+) sensor histidine kinase -
KHV89_RS21235 (4523494) 4523494..4524177 - 684 WP_047046104.1 copper response regulator transcription factor CusR -
KHV89_RS21240 (4524351) 4524351..4525736 + 1386 WP_103826224.1 efflux transporter outer membrane subunit -
KHV89_RS21245 (4525754) 4525754..4526098 + 345 WP_103826223.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19908.80 Da        Isoelectric Point: 5.2753

>T202183 WP_032715534.1 NZ_CP074446:c4521691-4521158 [Klebsiella aerogenes]
MDQLLTIEMIADEFRYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T202183 NZ_CP099338:1004159-1004311 [Escherichia fergusonii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT202183 WP_002887278.1 NZ_CP074446:c4521968-4521702 [Klebsiella aerogenes]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT202183 NZ_CP099338:c1004117-1004065 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLZ1

References