202171

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 267992..268623 Replicon chromosome
Accession NZ_CP074446
Organism Klebsiella aerogenes strain S2_CRE2

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H3FL31
Locus tag KHV89_RS01210 Protein ID WP_015703741.1
Coordinates 267992..268267 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H3FNK6
Locus tag KHV89_RS01215 Protein ID WP_015703740.1
Coordinates 268264..268623 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV89_RS01190 (263220) 263220..263555 + 336 WP_015703743.1 universal stress protein UspB -
KHV89_RS01195 (263621) 263621..265117 - 1497 WP_015369272.1 inorganic phosphate transporter PitA -
KHV89_RS01200 (265348) 265348..266541 + 1194 WP_103826161.1 NAD(P)/FAD-dependent oxidoreductase -
KHV89_RS01205 (266582) 266582..267595 - 1014 WP_015369274.1 magnesium transporter -
KHV89_RS01210 (267992) 267992..268267 + 276 WP_015703741.1 type II toxin-antitoxin system HicA family toxin Toxin
KHV89_RS01215 (268264) 268264..268623 + 360 WP_015703740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KHV89_RS01220 (268651) 268651..269052 - 402 WP_020077744.1 nickel-responsive transcriptional regulator NikR -
KHV89_RS01225 (269040) 269040..269831 - 792 WP_015369276.1 nickel import ATP-binding protein NikE -
KHV89_RS01230 (269828) 269828..270592 - 765 WP_015369277.1 nickel import ATP-binding protein NikD -
KHV89_RS01235 (270592) 270592..271425 - 834 WP_059444459.1 nickel ABC transporter permease subunit NikC -
KHV89_RS01240 (271422) 271422..272366 - 945 WP_045386598.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10258.89 Da        Isoelectric Point: 10.4888

>T202171 WP_015703741.1 NZ_CP074446:267992-268267 [Klebsiella aerogenes]
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T202171 NZ_CP099331:c4195517-4195410 [Escherichia fergusonii]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13305.02 Da        Isoelectric Point: 4.3472

>AT202171 WP_015703740.1 NZ_CP074446:268264-268623 [Klebsiella aerogenes]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp

>AT202171 NZ_CP099331:4195565-4195631 [Escherichia fergusonii]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FL31

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FNK6

References