Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4957127..4957643 Replicon chromosome
Accession NZ_CP074442
Organism Klebsiella pneumoniae strain S1_CRE1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KHV88_RS24615 Protein ID WP_002886902.1
Coordinates 4957127..4957411 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KHV88_RS24620 Protein ID WP_002886901.1
Coordinates 4957401..4957643 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV88_RS24590 (KHV88_24515) 4952611..4952874 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KHV88_RS24595 (KHV88_24520) 4953004..4953177 + 174 WP_002886906.1 hypothetical protein -
KHV88_RS24600 (KHV88_24525) 4953180..4953923 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KHV88_RS24605 (KHV88_24530) 4954280..4956418 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KHV88_RS24610 (KHV88_24535) 4956659..4957123 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KHV88_RS24615 (KHV88_24540) 4957127..4957411 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHV88_RS24620 (KHV88_24545) 4957401..4957643 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KHV88_RS24625 (KHV88_24550) 4957721..4959631 - 1911 WP_004152270.1 PRD domain-containing protein -
KHV88_RS24630 (KHV88_24555) 4959654..4960808 - 1155 WP_002886900.1 lactonase family protein -
KHV88_RS24635 (KHV88_24560) 4960874..4961614 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T202167 WP_002886902.1 NZ_CP074442:c4957411-4957127 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T202167 NZ_CP099331:c3494296-3493889 [Escherichia fergusonii]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGTTAAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCCCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCGCCGTGGATGATTAAAAGCGGCATGATGTTGCGTTTACGTTCTGATAGCGGTAAACGTCA
GCACTTGTGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT202167 WP_002886901.1 NZ_CP074442:c4957643-4957401 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT202167 NZ_CP099331:c3494543-3494277 [Escherichia fergusonii]
ATGGACATTAATAACAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGTGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References