Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2862243..2863831 Replicon chromosome
Accession NZ_CP074442
Organism Klebsiella pneumoniae strain S1_CRE1

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag KHV88_RS14275 Protein ID WP_002904792.1
Coordinates 2862243..2863565 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag KHV88_RS14280 Protein ID WP_002904790.1
Coordinates 2863565..2863831 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV88_RS14260 (KHV88_14205) 2857299..2859800 + 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -
KHV88_RS14265 (KHV88_14210) 2859788..2860792 + 1005 WP_002904798.1 fimbrial protein -
KHV88_RS14270 (KHV88_14215) 2860934..2862226 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
KHV88_RS14275 (KHV88_14220) 2862243..2863565 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
KHV88_RS14280 (KHV88_14225) 2863565..2863831 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KHV88_RS14285 (KHV88_14230) 2864097..2864423 - 327 WP_002904788.1 hydroxyisourate hydrolase -
KHV88_RS14290 (KHV88_14235) 2864420..2864920 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
KHV88_RS14295 (KHV88_14240) 2864898..2866277 - 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
KHV88_RS14300 (KHV88_14245) 2866623..2867777 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
KHV88_RS14305 (KHV88_14250) 2867758..2868681 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T202164 WP_002904792.1 NZ_CP074442:c2863565-2862243 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T202164 NZ_CP099331:c2755455-2755201 [Escherichia fergusonii]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACTCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT202164 WP_002904790.1 NZ_CP074442:c2863831-2863565 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT202164 NZ_CP099331:c2755703-2755452 [Escherichia fergusonii]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAACGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAAGAGACTGCTTATC
TATTGCGTTCCCCCGCTAATGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References