Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 873090..873747 Replicon chromosome
Accession NZ_CP074442
Organism Klebsiella pneumoniae strain S1_CRE1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KHV88_RS04415 Protein ID WP_002916310.1
Coordinates 873337..873747 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KHV88_RS04410 Protein ID WP_002916312.1
Coordinates 873090..873356 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV88_RS04385 (KHV88_04380) 868246..869679 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KHV88_RS04390 (KHV88_04385) 869798..870526 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KHV88_RS04395 (KHV88_04390) 870576..870887 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
KHV88_RS04400 (KHV88_04395) 871051..871710 + 660 WP_002916317.1 hemolysin III family protein -
KHV88_RS04405 (KHV88_04400) 871861..872844 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KHV88_RS04410 (KHV88_04405) 873090..873356 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KHV88_RS04415 (KHV88_04410) 873337..873747 + 411 WP_002916310.1 protein YgfX Toxin
KHV88_RS04420 (KHV88_04415) 873754..874275 - 522 WP_002916308.1 flavodoxin FldB -
KHV88_RS04425 (KHV88_04420) 874376..875272 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KHV88_RS04430 (KHV88_04425) 875295..876008 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KHV88_RS04435 (KHV88_04430) 876014..877747 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T202154 WP_002916310.1 NZ_CP074442:873337-873747 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T202154 NZ_CP099328:c4326433-4326326 [Escherichia fergusonii]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT202154 WP_002916312.1 NZ_CP074442:873090-873356 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202154 NZ_CP099328:4326481-4326547 [Escherichia fergusonii]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References