Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2214330..2214987 Replicon chromosome
Accession NZ_CP074437
Organism Klebsiella sp. A52

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag KGA69_RS10450 Protein ID WP_015369792.1
Coordinates 2214577..2214987 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag KGA69_RS10445 Protein ID WP_015369791.1
Coordinates 2214330..2214596 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGA69_RS10420 (2210799) 2210799..2211527 - 729 WP_045391997.1 MurR/RpiR family transcriptional regulator -
KGA69_RS10425 (2211578) 2211578..2211889 + 312 WP_045374015.1 N(4)-acetylcytidine aminohydrolase -
KGA69_RS10430 (2212054) 2212054..2212713 + 660 WP_008806429.1 hemolysin III family protein -
KGA69_RS10435 (2212779) 2212779..2213126 + 348 WP_213293073.1 hypothetical protein -
KGA69_RS10440 (2213123) 2213123..2214106 - 984 WP_213293075.1 tRNA-modifying protein YgfZ -
KGA69_RS10445 (2214330) 2214330..2214596 + 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
KGA69_RS10450 (2214577) 2214577..2214987 + 411 WP_015369792.1 protein YgfX Toxin
KGA69_RS10455 (2214995) 2214995..2215516 - 522 WP_015369793.1 flavodoxin FldB -
KGA69_RS10460 (2215617) 2215617..2216513 + 897 WP_015703420.1 site-specific tyrosine recombinase XerD -
KGA69_RS10465 (2216536) 2216536..2217249 + 714 WP_045374003.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KGA69_RS10470 (2217255) 2217255..2218988 + 1734 WP_045391988.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T202141 WP_015369792.1 NZ_CP074437:2214577-2214987 [Klebsiella sp. A52]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T202141 NZ_CP099328:c702252-702100 [Escherichia fergusonii]
ATGAAGCAGCATAAGGCGATGATAGTCGCTCTGATCGTCATCTGTGTCACCGCCATAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT202141 WP_015369791.1 NZ_CP074437:2214330-2214596 [Klebsiella sp. A52]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202141 NZ_CP099328:702301-702358 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References