Detailed information of TA system TA202138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 826833..827349
• Replicon: chromosome
• Accession: NZ_CP074437
• Organism: Klebsiella sp. A52

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KGA69_RS03795
• Protein ID: WP_045394697.1
• Coordinates: 826833..827117 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: KGA69_RS03800
• Protein ID: WP_002886901.1
• Coordinates: 827107..827349 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGA69_RS03775 (822085)	822085..822348	-	264	WP_015368564.1	PTS sugar transporter subunit IIB	-
KGA69_RS03780 (822655)	822655..823398	+	744	WP_045394700.1	MurR/RpiR family transcriptional regulator	-
KGA69_RS03785 (823755)	823755..825893	+	2139	WP_015368566.1	anaerobic ribonucleoside-triphosphate reductase	-
KGA69_RS03790 (826365)	826365..826829	+	465	WP_213292847.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
KGA69_RS03795 (826833)	826833..827117	-	285	WP_045394697.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGA69_RS03800 (827107)	827107..827349	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KGA69_RS03805 (827438)	827438..829348	-	1911	WP_045394695.1	PRD domain-containing protein	-
KGA69_RS03810 (829371)	829371..830522	-	1152	WP_213292848.1	lactonase family protein	-
KGA69_RS03815 (830708)	830708..831448	-	741	WP_045394691.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11127.96 Da
• Isoelectric Point: 10.3787

>T202138 WP_045394697.1 NZ_CP074437:c827117-826833 [Klebsiella sp. A52]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQVVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T202138 NZ_CP099327:c1025889-1025671 [Enterobacter ludwigii]
ATGTCTGAAAAACCACTCACAAAAATCGATTATTTGATGCGTTTGCGACGCTGTCAGTCAATAGACACGCTTGAACGTGT
AATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCGGCTGACCACCGTCTTGCTGAAC
TGACCATGAATAAGCTGTATGACAAAATCCCAACGTCCGTGTGGAGATTTGTCCGTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT202138 WP_002886901.1 NZ_CP074437:c827349-827107 [Klebsiella sp. A52]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT202138 NZ_CP099327:c1026291-1025917 [Enterobacter ludwigii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTAAACGAGTTGATCGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGATGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGCTACGGCATTAATGCGCAAGATTTGCAGAAATGGCGTAAATCGGGCAACCGACT
ATTTCGTTGCTTCATCAACGTGAGCAGAGCTAACCCCGTTAGTCTTTCCTGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0