Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4179510..4180291 Replicon chromosome
Accession NZ_CP074428
Organism Salmonella sp. SJTUF14523

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag KFD69_RS20360 Protein ID WP_000626100.1
Coordinates 4179510..4180001 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag KFD69_RS20365 Protein ID WP_001110452.1
Coordinates 4179998..4180291 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFD69_RS20325 (4174970) 4174970..4175317 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
KFD69_RS20330 (4175293) 4175293..4176996 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
KFD69_RS20335 (4177033) 4177033..4177608 + 576 WP_001188509.1 transcriptional regulator -
KFD69_RS20345 (4177879) 4177879..4177953 - 75 Protein_3994 helix-turn-helix domain-containing protein -
KFD69_RS20350 (4178333) 4178333..4178410 + 78 Protein_3995 porin family protein -
KFD69_RS20355 (4178510) 4178510..4179262 + 753 WP_000842433.1 non-specific acid phosphatase -
KFD69_RS20360 (4179510) 4179510..4180001 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
KFD69_RS20365 (4179998) 4179998..4180291 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
KFD69_RS20370 (4180608) 4180608..4180829 + 222 WP_001576552.1 hypothetical protein -
KFD69_RS20375 (4181095) 4181095..4181970 + 876 WP_000921676.1 AraC family transcriptional regulator -
KFD69_RS20380 (4181967) 4181967..4182254 + 288 WP_001541332.1 transcriptional regulator RtsB -
KFD69_RS20385 (4182247) 4182247..4182555 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
KFD69_RS20390 (4182554) 4182554..4182802 + 249 Protein_4003 Ig-like domain-containing protein -
KFD69_RS23945 (4182914) 4182914..4183045 + 132 Protein_4004 hypothetical protein -
KFD69_RS20395 (4183339) 4183339..4184244 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T202129 WP_000626100.1 NZ_CP074428:c4180001-4179510 [Salmonella sp. SJTUF14523]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T202129 NZ_CP099323:2297847-2298332 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTACTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT202129 WP_001110452.1 NZ_CP074428:c4180291-4179998 [Salmonella sp. SJTUF14523]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT202129 NZ_CP099323:2297593-2297859 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTCGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References