Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4031489..4032039 Replicon chromosome
Accession NZ_CP074428
Organism Salmonella sp. SJTUF14523

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag KFD69_RS19580 Protein ID WP_001199743.1
Coordinates 4031489..4031797 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag KFD69_RS19585 Protein ID WP_001118105.1
Coordinates 4031800..4032039 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFD69_RS19560 (4028063) 4028063..4028803 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
KFD69_RS19565 (4028925) 4028925..4029455 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
KFD69_RS19570 (4029778) 4029778..4030911 + 1134 Protein_3844 IS3 family transposase -
KFD69_RS19575 (4030943) 4030943..4031083 - 141 Protein_3845 Arm DNA-binding domain-containing protein -
KFD69_RS19580 (4031489) 4031489..4031797 - 309 WP_001199743.1 CcdB family protein Toxin
KFD69_RS19585 (4031800) 4031800..4032039 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
KFD69_RS19590 (4032148) 4032148..4032396 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
KFD69_RS19595 (4032587) 4032587..4033018 - 432 Protein_3849 helix-turn-helix domain-containing protein -
KFD69_RS19605 (4033775) 4033775..4034794 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
KFD69_RS19610 (4034822) 4034822..4035352 - 531 WP_000896758.1 gluconokinase -
KFD69_RS19615 (4035569) 4035569..4036600 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4029870..4032973 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T202127 WP_001199743.1 NZ_CP074428:c4031797-4031489 [Salmonella sp. SJTUF14523]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T202127 NZ_CP099323:898266-898676 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT202127 WP_001118105.1 NZ_CP074428:c4032039-4031800 [Salmonella sp. SJTUF14523]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT202127 NZ_CP099323:898019-898285 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References