Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3411699..3412319 Replicon chromosome
Accession NZ_CP074428
Organism Salmonella sp. SJTUF14523

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag KFD69_RS16720 Protein ID WP_001280991.1
Coordinates 3412101..3412319 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag KFD69_RS16715 Protein ID WP_000344807.1
Coordinates 3411699..3412073 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFD69_RS16705 (3406838) 3406838..3408031 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KFD69_RS16710 (3408054) 3408054..3411203 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
KFD69_RS16715 (3411699) 3411699..3412073 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
KFD69_RS16720 (3412101) 3412101..3412319 + 219 WP_001280991.1 HHA domain-containing protein Toxin
KFD69_RS16725 (3412498) 3412498..3413049 + 552 WP_001278793.1 maltose O-acetyltransferase -
KFD69_RS16730 (3413167) 3413167..3413637 + 471 WP_000136183.1 YlaC family protein -
KFD69_RS16735 (3413693) 3413693..3413833 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
KFD69_RS16740 (3413839) 3413839..3414099 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
KFD69_RS16745 (3414324) 3414324..3415874 + 1551 WP_000213140.1 EAL domain-containing protein -
KFD69_RS16755 (3416105) 3416105..3416494 + 390 WP_000961287.1 MGMT family protein -
KFD69_RS16760 (3416527) 3416527..3417096 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T202122 WP_001280991.1 NZ_CP074428:3412101-3412319 [Salmonella sp. SJTUF14523]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T202122 NZ_CP099318:c3800804-3800394 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGCGCGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT202122 WP_000344807.1 NZ_CP074428:3411699-3412073 [Salmonella sp. SJTUF14523]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT202122 NZ_CP099318:c3801051-3800785 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References