Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 988514..989328 Replicon chromosome
Accession NZ_CP074428
Organism Salmonella sp. SJTUF14523

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag KFD69_RS04720 Protein ID WP_000971655.1
Coordinates 988514..989041 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag KFD69_RS04725 Protein ID WP_000855694.1
Coordinates 989038..989328 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFD69_RS04695 (984803) 984803..985201 + 399 Protein_918 cytoplasmic protein -
KFD69_RS04700 (985787) 985787..986455 + 669 WP_000445914.1 hypothetical protein -
KFD69_RS04705 (986482) 986482..986976 + 495 WP_000424949.1 hypothetical protein -
KFD69_RS04710 (987221) 987221..987877 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
KFD69_RS04715 (988236) 988236..988441 + 206 Protein_922 IS5/IS1182 family transposase -
KFD69_RS04720 (988514) 988514..989041 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
KFD69_RS04725 (989038) 989038..989328 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
KFD69_RS04730 (989598) 989598..989787 - 190 Protein_925 IS3 family transposase -
KFD69_RS04735 (990191) 990191..990634 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
KFD69_RS04740 (991090) 991090..991740 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
KFD69_RS04745 (991737) 991737..993425 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 988265..988441 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T202111 WP_000971655.1 NZ_CP074428:c989041-988514 [Salmonella sp. SJTUF14523]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T202111 NZ_CP099316:c2706236-2706133 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT202111 WP_000855694.1 NZ_CP074428:c989328-989038 [Salmonella sp. SJTUF14523]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT202111 NZ_CP099316:2706120-2706329 [Enterobacter hormaechei]
TTTTCAAGCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTA
AAAGTGGTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References