Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 825027..825687 Replicon chromosome
Accession NZ_CP074428
Organism Salmonella sp. SJTUF14523

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag KFD69_RS03975 Protein ID WP_000244756.1
Coordinates 825274..825687 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag KFD69_RS03970 Protein ID WP_000351186.1
Coordinates 825027..825293 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFD69_RS03950 (820956) 820956..822389 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
KFD69_RS03955 (822547) 822547..822858 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
KFD69_RS03960 (823022) 823022..823681 + 660 WP_000250289.1 hemolysin III family protein -
KFD69_RS03965 (823797) 823797..824777 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
KFD69_RS03970 (825027) 825027..825293 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
KFD69_RS03975 (825274) 825274..825687 + 414 WP_000244756.1 protein YgfX Toxin
KFD69_RS03980 (825740) 825740..826261 - 522 WP_001055885.1 flavodoxin FldB -
KFD69_RS03985 (826374) 826374..827270 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
KFD69_RS03990 (827294) 827294..828007 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KFD69_RS03995 (828013) 828013..829746 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T202109 WP_000244756.1 NZ_CP074428:825274-825687 [Salmonella sp. SJTUF14523]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T202109 NZ_CP099316:1696205-1696726 [Enterobacter hormaechei]
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
CAATGCCTTCCTTACCGAGCACCTGGTGCGTCAGCATGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCCTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATAGAACGACTGTTTGAGCAGGCGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT202109 WP_000351186.1 NZ_CP074428:825027-825293 [Salmonella sp. SJTUF14523]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202109 NZ_CP099316:1695929-1696198 [Enterobacter hormaechei]
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References