Detailed information of TA system TA202107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 310307..310893
• Replicon: chromosome
• Accession: NZ_CP074428
• Organism: Salmonella sp. SJTUF14523

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A3V9X0E4
• Locus tag: KFD69_RS01415
• Protein ID: WP_000174964.1
• Coordinates: 310525..310893 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: V7IU48
• Locus tag: KFD69_RS01410
• Protein ID: WP_001522145.1
• Coordinates: 310307..310528 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFD69_RS01385 (305328)	305328..306437	+	1110	WP_000822978.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
KFD69_RS01390 (306497)	306497..307423	+	927	WP_000003007.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
KFD69_RS01395 (307420)	307420..308697	+	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
KFD69_RS01400 (308694)	308694..309461	+	768	WP_000082080.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
KFD69_RS01405 (309463)	309463..310176	+	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
KFD69_RS01410 (310307)	310307..310528	+	222	WP_001522145.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KFD69_RS01415 (310525)	310525..310893	+	369	WP_000174964.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
KFD69_RS01420 (311152)	311152..312468	+	1317	WP_000624755.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
KFD69_RS01425 (312573)	312573..313460	+	888	WP_000099303.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
KFD69_RS01430 (313457)	313457..314302	+	846	WP_000572196.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
KFD69_RS01435 (314304)	314304..315374	+	1071	WP_000907840.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	308694..316111	7417

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (6-114)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13601.91 Da
• Isoelectric Point: 6.7252

>T202107 WP_000174964.1 NZ_CP074428:310525-310893 [Salmonella sp. SJTUF14523]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Nucleotide

• Length: 369 bp

>T202107 NZ_CP099316:c1092074-1091001 [Enterobacter hormaechei]
ATGACAGTCAGAAGTTATAAGGATTTAAATCTGGTCAGGGCTAACATCGAAACTGAATGCAGGCAGTTCATTCAAACCAG
AACGTATGCAATTCAGTCAATTGGCCCGATGCCGGGGCAAAAACCCGGACTCAGAGTGACATTCGCGAAAACAGGAGAGA
ACTTCGCTACCGTTAACATTTTCTATAACGGCGATGGCTCGTCTACAGTTCAGTATCTTACGGGGGCTAATCAGTCTCTG
GGTAAGGAGCTTGCTGATTACCTTTTTGAAACCATTAACCCTGAAGAATTTGAACATGTAAATATGGTCGTGGAAGGGTT
TGTGGAGGACTCAATTTTTCCTGTGCTTGAGTTATCAGCAGAAGAAACGCATATTGAGTTCTGGGAACACCTTCGTAACA
CTCACTCCATCGTGTGGAAAATCACCTCTACTACCTACCAAGATGAATTGACGGTTACCCTGTACACCACTACAGGCAAG
CTTCAGATTCAAGGACGCCCGCTATCCTGCTATCGGGTTTTTACCTTCAATCTGGCAGAACTGCTTAATTTGCAAGGTCT
GGAAAAAGTGTTGATTCGCCAAGATGATGGCAAAGCGAACATTGTTCAACAGGAAGTAGCCCGCGCTAACCTGGAGTCTA
TAATGGGTGATGCTTATCCTCACTTGCACGTCACTGCTGAAAAATTGCTCATTTCAGGTCTATGTGTTAAGCTTGCCGCC
CCTAAATTGCCAGACTACTGCATGTTGCTTTACCCGGAACTTCGCTCCGTTGAGGGTGTCTTAAAGAATAAAATGTACAC
ATTTGGCATGTCTGTACAGCAACCTTTAGGGTTTGGGCCTTTTTTCGATAAGGTTGGCTTAAATTTCATTTTGAAACCAC
AATATGCGGCTCCTCTCAGGCCAGAGCAGGCTAATGCCATCAATGAAGCCTATACTTTCTGGAATGCGGAACGTCATGCT
GTGTTTCACATGGAAACAGCGGTAGATTCCAGCCGCATGATTTCTGATATGGCCCGACTAATGACCAAAGCCACTAAAGC
GTGGCAAATAATCAAGGATTTGTATCTTGTTTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8166.17 Da
• Isoelectric Point: 5.0775

>AT202107 WP_001522145.1 NZ_CP074428:310307-310528 [Salmonella sp. SJTUF14523]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Nucleotide

• Length: 222 bp

>AT202107 NZ_CP099316:c1091008-1090628 [Enterobacter hormaechei]
TTGTTTGAAATTACCGGAGTTAACGTTTCAGGATCTCTTAAAGCTGTCGTTATGGCGACCGGCTACGAGAACCCGTTGTC
TTCAGTCAACGAAATTGAGACGAAACTCACTGACCTGCTGGGCCAGAATGAAAATGGTAAAATCCTTTTCGACCTCCTAT
GCGCTAACGGTCTTGAGTGGAACCGGTTTGTTACGCTTGAAATGAAATATGGCCGCATCATGCTGGATTCGGCCAAAATT
ATTGATGTGCAGGAAATACCAGCACAGATCCTGAGTAAACTAACCTTTACTTTACTGAATCACCCTGAGTACCTAGAAGC
GTCCGTATTGACTCACGATGACGTACGCCAAGTCCTTTCAATGGATATGCAAGGGGCTTGA

Structures

Toxin

• AlphaFold DB: A0A3V9X0E4