Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 38961..39486 | Replicon | plasmid p15034B |
| Accession | NZ_CP074427 | ||
| Organism | Salmonella sp. SJTUF15034 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | KFD68_RS23570 | Protein ID | WP_001159863.1 |
| Coordinates | 39181..39486 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | KFD68_RS23565 | Protein ID | WP_000813641.1 |
| Coordinates | 38961..39179 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFD68_RS23535 (KFD68_23520) | 33986..34411 | + | 426 | WP_213680248.1 | IS200/IS605 family transposase | - |
| KFD68_RS23540 (KFD68_23525) | 34538..35188 | - | 651 | WP_001676646.1 | SPI-2 type III secretion system effector cysteine hydrolase SpvD | - |
| KFD68_RS23545 (KFD68_23530) | 35502..36491 | - | 990 | WP_000461382.1 | RepB family plasmid replication initiator protein | - |
| KFD68_RS23550 (KFD68_23535) | 36985..37280 | - | 296 | Protein_54 | cytoplasmic protein | - |
| KFD68_RS23555 (KFD68_23540) | 37292..37720 | + | 429 | Protein_55 | hypothetical protein | - |
| KFD68_RS23560 (KFD68_23545) | 37764..38285 | - | 522 | WP_077681952.1 | hypothetical protein | - |
| KFD68_RS23565 (KFD68_23550) | 38961..39179 | + | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| KFD68_RS23570 (KFD68_23555) | 39181..39486 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| KFD68_RS23575 (KFD68_23560) | 39488..39778 | + | 291 | WP_001266176.1 | hypothetical protein | - |
| KFD68_RS23580 (KFD68_23565) | 39775..40296 | + | 522 | WP_000198608.1 | hypothetical protein | - |
| KFD68_RS23585 (KFD68_23570) | 40331..41113 | + | 783 | WP_000082169.1 | site-specific integrase | - |
| KFD68_RS23590 (KFD68_23575) | 41122..41835 | + | 714 | WP_121212594.1 | EAL domain-containing protein | - |
| KFD68_RS23595 (KFD68_23580) | 41860..42348 | + | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| KFD68_RS23600 (KFD68_23585) | 42342..42827 | + | 486 | WP_000905606.1 | membrane protein | - |
| KFD68_RS23605 (KFD68_23590) | 43104..43391 | - | 288 | WP_071530243.1 | hypothetical protein | - |
| KFD68_RS23610 (KFD68_23595) | 43547..44107 | + | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | rck / pefD / pefC / pefA / pefB / fdeC / fdeC / spvC / spvB | 1..70795 | 70795 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T202105 WP_001159863.1 NZ_CP074427:39181-39486 [Salmonella sp. SJTUF15034]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
>T202105 NZ_CP099314:c4622911-4622540 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTATTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGAGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTATTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGAGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG
Antitoxin
Download Length: 73 a.a. Molecular weight: 8314.16 Da Isoelectric Point: 4.5203
>AT202105 WP_000813641.1 NZ_CP074427:38961-39179 [Salmonella sp. SJTUF15034]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
Download Length: 219 bp
>AT202105 NZ_CP099314:c4623156-4622914 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |