Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 28366..28891 | Replicon | plasmid p15034B |
| Accession | NZ_CP074427 | ||
| Organism | Salmonella sp. SJTUF15034 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | KFD68_RS23485 | Protein ID | WP_001159863.1 |
| Coordinates | 28586..28891 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | KFD68_RS23480 | Protein ID | WP_000813641.1 |
| Coordinates | 28366..28584 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFD68_RS23450 (KFD68_23435) | 23980..24366 | + | 387 | WP_000751876.1 | YgiW/YdeI family stress tolerance OB fold protein | - |
| KFD68_RS23455 (KFD68_23440) | 24419..24538 | + | 120 | Protein_35 | recombinase | - |
| KFD68_RS23460 (KFD68_23445) | 24907..25896 | - | 990 | WP_000461382.1 | RepB family plasmid replication initiator protein | - |
| KFD68_RS23465 (KFD68_23450) | 26390..26685 | - | 296 | Protein_37 | cytoplasmic protein | - |
| KFD68_RS23470 (KFD68_23455) | 26697..27125 | + | 429 | Protein_38 | hypothetical protein | - |
| KFD68_RS23475 (KFD68_23460) | 27169..27690 | - | 522 | WP_077681952.1 | hypothetical protein | - |
| KFD68_RS23480 (KFD68_23465) | 28366..28584 | + | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| KFD68_RS23485 (KFD68_23470) | 28586..28891 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| KFD68_RS23490 (KFD68_23475) | 28893..29183 | + | 291 | WP_001266176.1 | hypothetical protein | - |
| KFD68_RS23495 (KFD68_23480) | 29180..29701 | + | 522 | WP_000198608.1 | hypothetical protein | - |
| KFD68_RS23500 (KFD68_23485) | 29736..30518 | + | 783 | WP_000082169.1 | site-specific integrase | - |
| KFD68_RS23505 (KFD68_23490) | 30527..31240 | + | 714 | WP_121212594.1 | EAL domain-containing protein | - |
| KFD68_RS23510 (KFD68_23495) | 31265..31753 | + | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| KFD68_RS23515 (KFD68_23500) | 31747..32232 | + | 486 | WP_000905606.1 | membrane protein | - |
| KFD68_RS23520 (KFD68_23505) | 32509..32796 | - | 288 | WP_071530243.1 | hypothetical protein | - |
| KFD68_RS23525 (KFD68_23510) | 32952..33512 | + | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | rck / pefD / pefC / pefA / pefB / fdeC / fdeC / spvC / spvB | 1..70795 | 70795 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T202104 WP_001159863.1 NZ_CP074427:28586-28891 [Salmonella sp. SJTUF15034]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
>T202104 NZ_CP099314:c3820838-3820428 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8314.16 Da Isoelectric Point: 4.5203
>AT202104 WP_000813641.1 NZ_CP074427:28366-28584 [Salmonella sp. SJTUF15034]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
Download Length: 219 bp
>AT202104 NZ_CP099314:c3821085-3820819 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |