Detailed information of TA system TA202103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 59901..60423
• Replicon: plasmid p15034A
• Accession: NZ_CP074426
• Organism: Salmonella sp. SJTUF15034

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D0QMR1
• Locus tag: KFD68_RS23020
• Protein ID: WP_000220561.1
• Coordinates: 60142..60423 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: KFD68_RS23015
• Protein ID: WP_000121743.1
• Coordinates: 59901..60152 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFD68_RS22995 (56024)	56024..56377	-	354	WP_024129958.1	DNA distortion polypeptide 3	-
KFD68_RS23000 (56514)	56514..56960	-	447	WP_001074384.1	hypothetical protein	-
KFD68_RS23005 (56964)	56964..57806	-	843	WP_000435064.1	replication initiation protein	-
KFD68_RS23010 (57827)	57827..58666	-	840	WP_024129959.1	replication initiation protein	-
KFD68_RS23015 (59901)	59901..60152	+	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
KFD68_RS23020 (60142)	60142..60423	+	282	WP_000220561.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KFD68_RS23025 (60662)	60662..60754	-	93	Protein_77	IS6 family transposase	-
KFD68_RS23030 (60920)	60920..62119	-	1200	WP_072648941.1	IS91 family transposase	-
KFD68_RS23035 (62129)	62129..62317	-	189	WP_000957857.1	hypothetical protein	-
KFD68_RS23040 (62437)	62437..63867	+	1431	Protein_80	IS4-like element IS50R family transposase	-
KFD68_RS23045 (63896)	63896..64690	+	795	WP_000572405.1	aminoglycoside O-phosphotransferase APH(3')-IIa	-
KFD68_RS23050 (64711)	64711..64947	+	237	Protein_82	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	aph(3')-IIa / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / blaTEM-1B / blaCTX-M-55	-	1..101606	101606
	-	flank	IS/Tn	-	-	54339..55538	1199

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11023.86 Da
• Isoelectric Point: 10.5938

>T202103 WP_000220561.1 NZ_CP074426:60142-60423 [Salmonella sp. SJTUF15034]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Nucleotide

• Length: 282 bp

>T202103 NZ_CP099314:3593740-3594039 [Enterobacter hormaechei]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TGTATGAAGCATTGAGTCCTCCGTTGAAGGGATATTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9194.43 Da
• Isoelectric Point: 4.1683

>AT202103 WP_000121743.1 NZ_CP074426:59901-60152 [Salmonella sp. SJTUF15034]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Nucleotide

• Length: 252 bp

>AT202103 NZ_CP099314:3594050-3594415 [Enterobacter hormaechei]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGATGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAGCGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCAGACGTTACCCTGCACGGGAACAGCGCATAA

Structures

Toxin

• AlphaFold DB: A0A3S5I302

Antitoxin

• AlphaFold DB: A0A3S5I301