Detailed information of TA system TA020210

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1967705..1968165
• Replicon: chromosome
• Accession: NC_000962
• Organism: Mycobacterium tuberculosis H37Rv

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF71
• Locus tag: Rv1741
• Protein ID: NP_216257.1
• Coordinates: 1967917..1968165 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ31
• Locus tag: Rv1740
• Protein ID: NP_216256.1
• Coordinates: 1967705..1967917 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Rv1737c	1964183..1965370	-	1188	NP_216253.1	nitrate/nitrite transporter	-
Rv1738	1965657..1965941	+	285	NP_216254.1	hypothetical protein	-
Rv1739c	1965955..1967637	-	1683	NP_216255.1	sulfate ABC transporter permease	-
Rv1740	1967705..1967917	+	213	NP_216256.1	antitoxin VapB34	Antitoxin
Rv1741	1967917..1968165	+	249	NP_216257.1	ribonuclease VapC34	Toxin
Rv1742	1968173..1968910	+	738	NP_216258.1	hypothetical protein	-
Rv1743	1969004..1970704	+	1701	NP_216259.1	serine/threonine-protein kinase PknE	-
Rv1744c	1970989..1971390	-	402	NP_216260.1	membrane protein	-
Rv1745c	1971380..1971991	-	612	NP_216261.1	isopentenyl-diphosphate delta-isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin VapB-like (2-69)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 8884.14 Da
• Isoelectric Point: 4.1074

>T20210 NP_216257.1 NC_000962:1967917-1968165 [Mycobacterium tuberculosis H37Rv]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Nucleotide

• Length: 249 bp

>T20210 NC_000962:1967917-1968165 [Mycobacterium tuberculosis H37Rv]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7607.80 Da
• Isoelectric Point: 9.3146

>AT20210 NP_216256.1 NC_000962:1967705-1967917 [Mycobacterium tuberculosis H37Rv]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Nucleotide

• Length: 213 bp

>AT20210 NC_000962:1967705-1967917 [Mycobacterium tuberculosis H37Rv]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Structures

Toxin

• AlphaFold DB: P9WF71

Antitoxin

• AlphaFold DB: P9WJ31