Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4178945..4179726 Replicon chromosome
Accession NZ_CP074425
Organism Salmonella sp. SJTUF15034

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag KFD68_RS20360 Protein ID WP_000626100.1
Coordinates 4178945..4179436 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag KFD68_RS20365 Protein ID WP_001110452.1
Coordinates 4179433..4179726 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFD68_RS20325 (4174405) 4174405..4174752 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
KFD68_RS20330 (4174728) 4174728..4176431 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
KFD68_RS20335 (4176468) 4176468..4177043 + 576 WP_001188509.1 transcriptional regulator -
KFD68_RS20345 (4177314) 4177314..4177388 - 75 Protein_3994 helix-turn-helix domain-containing protein -
KFD68_RS20350 (4177768) 4177768..4177845 + 78 Protein_3995 porin family protein -
KFD68_RS20355 (4177945) 4177945..4178697 + 753 WP_000842433.1 non-specific acid phosphatase -
KFD68_RS20360 (4178945) 4178945..4179436 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
KFD68_RS20365 (4179433) 4179433..4179726 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
KFD68_RS20370 (4180043) 4180043..4180264 + 222 WP_001576552.1 hypothetical protein -
KFD68_RS20375 (4180530) 4180530..4181405 + 876 WP_000921676.1 AraC family transcriptional regulator -
KFD68_RS20380 (4181402) 4181402..4181689 + 288 WP_001541332.1 transcriptional regulator RtsB -
KFD68_RS20385 (4181682) 4181682..4181990 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
KFD68_RS20390 (4181989) 4181989..4182237 + 249 Protein_4003 Ig-like domain-containing protein -
KFD68_RS24000 (4182349) 4182349..4182480 + 132 Protein_4004 hypothetical protein -
KFD68_RS20395 (4182774) 4182774..4183679 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T202094 WP_000626100.1 NZ_CP074425:c4179436-4178945 [Salmonella sp. SJTUF15034]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T202094 NZ_CP099311:4196294-4196671 [Enterobacter ludwigii]
ATGCAAACCCAATCGAGATCCCCAACGCGGGAGGCTTCACCACGCCCGTCACCCGTGGAGATCTGGCTGCGCCTCCTGAG
TCACCTGCTGGAGCACCACTACGGTCTGACGCTCAACGACACACCTTTCGGCAACGATGGCGTGATTCAGGAGCATATTG
ACGCCGGTATATCACTGTGCGATGCCGTGAATTTTATTGTGGAAAAATACGATTTGGTTCGCACCGATCGTCACGGCTTC
AGTGCCGAAACACAGTCGCCGCTTCTCACCCGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACCCGCAA
CGATTACAGAACGGTGACCGATATCACCACCGGTAAATACCGCGAGGTGCAGCAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT202094 WP_001110452.1 NZ_CP074425:c4179726-4179433 [Salmonella sp. SJTUF15034]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT202094 NZ_CP099311:4195883-4196242 [Enterobacter ludwigii]
TTGTCGAATGAAATACCGGCAGTAAACCACGATATTGCCGACCCCTGGTGGGGGCTTAAACGCAATATCACCCCCTGTTT
TGGCGCTCGTCTGGTGCAGGAGGGCAACCGGCTGCACTACCTGGCCGACCGCGCCAGCATCACCGGTCAGTTCAGCGAGG
CGGATTTACGTCATCTCGACCTGGCGTTCCCGGTATTAATGAAGCAGATGGAACTGATGCTGGTTTCCGGTGAGCTCAAT
CCCCGCCATCAGCACTGTGTCACGCTGTATGCGAAAGGGCTGACCTGCGAGGCCGACAGCCTCGGTTCGCATGGGTATGT
CTATATCGCGATTTACCCGACACCTGCAACAACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References