Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4072049..4072565 Replicon chromosome
Accession NZ_CP074425
Organism Salmonella sp. SJTUF15034

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag KFD68_RS19790 Protein ID WP_000220582.1
Coordinates 4072049..4072333 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag KFD68_RS19795 Protein ID WP_000212724.1
Coordinates 4072323..4072565 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFD68_RS19775 (4067260) 4067260..4068912 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
KFD68_RS19780 (4069321) 4069321..4071459 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
KFD68_RS19785 (4071581) 4071581..4072045 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KFD68_RS19790 (4072049) 4072049..4072333 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFD68_RS19795 (4072323) 4072323..4072565 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KFD68_RS19800 (4072643) 4072643..4074556 - 1914 WP_001212142.1 BglG family transcription antiterminator -
KFD68_RS19805 (4074573) 4074573..4075313 - 741 WP_000779259.1 KDGP aldolase family protein -
KFD68_RS19810 (4075310) 4075310..4076428 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
KFD68_RS19815 (4076412) 4076412..4077545 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T202093 WP_000220582.1 NZ_CP074425:c4072333-4072049 [Salmonella sp. SJTUF15034]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T202093 NZ_CP099311:c4036001-4035591 [Enterobacter ludwigii]
GTGGTCCTATGGCAATCTGACCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTGTTGCTCCACGGCCTGGTCGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGCTGTTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGCCGCATTCATGCCCGTCAGGGGGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATTCTCGGTATGCCCTGGATGATCGCTTCCGGCATGATGCTGCGGCTACGTAGCGTGGACAGCGGGCGTCG
CCAGCATCTGTGGCTGGCCGCGGACAGTATGGATAGCGCTGAGTGGCGAGACCTGCGTCGGATGTTATTACAGCAGCTGA
CGCAGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT202093 WP_000212724.1 NZ_CP074425:c4072565-4072323 [Salmonella sp. SJTUF15034]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT202093 NZ_CP099311:c4036248-4035982 [Enterobacter ludwigii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTATGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References