Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4030924..4031474 Replicon chromosome
Accession NZ_CP074425
Organism Salmonella sp. SJTUF15034

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag KFD68_RS19580 Protein ID WP_001199743.1
Coordinates 4030924..4031232 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag KFD68_RS19585 Protein ID WP_001118105.1
Coordinates 4031235..4031474 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFD68_RS19560 (4027498) 4027498..4028238 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
KFD68_RS19565 (4028360) 4028360..4028890 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
KFD68_RS19570 (4029213) 4029213..4030346 + 1134 Protein_3844 IS3 family transposase -
KFD68_RS19575 (4030378) 4030378..4030518 - 141 Protein_3845 Arm DNA-binding domain-containing protein -
KFD68_RS19580 (4030924) 4030924..4031232 - 309 WP_001199743.1 CcdB family protein Toxin
KFD68_RS19585 (4031235) 4031235..4031474 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
KFD68_RS19590 (4031583) 4031583..4031831 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
KFD68_RS19595 (4032022) 4032022..4032453 - 432 Protein_3849 helix-turn-helix domain-containing protein -
KFD68_RS19605 (4033210) 4033210..4034229 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
KFD68_RS19610 (4034257) 4034257..4034787 - 531 WP_000896758.1 gluconokinase -
KFD68_RS19615 (4035004) 4035004..4036035 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4029305..4032408 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T202092 WP_001199743.1 NZ_CP074425:c4031232-4030924 [Salmonella sp. SJTUF15034]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T202092 NZ_CP099311:c2955850-2955747 [Enterobacter ludwigii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT202092 WP_001118105.1 NZ_CP074425:c4031474-4031235 [Salmonella sp. SJTUF15034]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT202092 NZ_CP099311:2955740-2955885 [Enterobacter ludwigii]
AATAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References