Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3986663..3987239 Replicon chromosome
Accession NZ_CP074425
Organism Salmonella sp. SJTUF15034

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag KFD68_RS19370 Protein ID WP_001131963.1
Coordinates 3986952..3987239 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag KFD68_RS19365 Protein ID WP_000063142.1
Coordinates 3986663..3986965 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFD68_RS19350 (3983173) 3983173..3985323 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
KFD68_RS19355 (3985418) 3985418..3985621 + 204 WP_000460616.1 YbdD/YjiX family protein -
KFD68_RS19360 (3985632) 3985632..3986588 + 957 WP_000187843.1 GTPase -
KFD68_RS19365 (3986663) 3986663..3986965 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
KFD68_RS19370 (3986952) 3986952..3987239 - 288 WP_001131963.1 BrnT family toxin Toxin
KFD68_RS19375 (3987656) 3987656..3988912 + 1257 Protein_3805 NERD domain-containing protein/DEAD/DEAH box helicase -
KFD68_RS19380 (3988906) 3988906..3989085 + 180 Protein_3806 DNA methyltransferase -
KFD68_RS19385 (3989075) 3989075..3990379 + 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T202091 WP_001131963.1 NZ_CP074425:c3987239-3986952 [Salmonella sp. SJTUF15034]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T202091 NZ_CP099311:c1033661-1033443 [Enterobacter ludwigii]
ATGTCTGAAAAACCACTCACAAAAATCGATTATTTGATGCGTTTGCGACGCTGTCAGTCAATAGACACGCTTGAACGTGT
AATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCGGCTGACCACCGTCTTGCAGAAC
TGACTATGAATAAGCTGTATGACAAAATCCCAACGTCCGTGTGGAGATTTGTCCGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT202091 WP_000063142.1 NZ_CP074425:c3986965-3986663 [Salmonella sp. SJTUF15034]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT202091 NZ_CP099311:c1034063-1033689 [Enterobacter ludwigii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTAAACGAGTTGATCGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGATGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGCTACGGCATTAATGCGCAAGATTTGCAGAAATGGCGTAAATCGGGCAACCGACT
ATTTCGTTGCTTCATCAACGTGAGCAGAGCTAACCCCGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References