Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3411133..3411753 Replicon chromosome
Accession NZ_CP074425
Organism Salmonella sp. SJTUF15034

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag KFD68_RS16720 Protein ID WP_001280991.1
Coordinates 3411535..3411753 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag KFD68_RS16715 Protein ID WP_000344807.1
Coordinates 3411133..3411507 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFD68_RS16705 (3406272) 3406272..3407465 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KFD68_RS16710 (3407488) 3407488..3410637 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
KFD68_RS16715 (3411133) 3411133..3411507 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
KFD68_RS16720 (3411535) 3411535..3411753 + 219 WP_001280991.1 HHA domain-containing protein Toxin
KFD68_RS16725 (3411932) 3411932..3412483 + 552 WP_001278793.1 maltose O-acetyltransferase -
KFD68_RS16730 (3412601) 3412601..3413071 + 471 WP_000136183.1 YlaC family protein -
KFD68_RS16735 (3413127) 3413127..3413267 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
KFD68_RS16740 (3413273) 3413273..3413533 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
KFD68_RS16745 (3413758) 3413758..3415308 + 1551 WP_000213140.1 EAL domain-containing protein -
KFD68_RS16755 (3415539) 3415539..3415928 + 390 WP_000961287.1 MGMT family protein -
KFD68_RS16760 (3415961) 3415961..3416530 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T202087 WP_001280991.1 NZ_CP074425:3411535-3411753 [Salmonella sp. SJTUF15034]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T202087 NZ_CP099310:c1043518-1043300 [Enterobacter ludwigii]
ATGTCTGAAAAACCACTCACAAAAATCGATTATTTGATGCGTTTGCGACGCTGCCAGTCAATAGACACGCTTGAACGTGT
AATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCGGCTGACCACCGTCTTGCAGAAC
TGACCATGAATAAGCTGTATGACAAAATCCCAACGTCCGTGTGGAGATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT202087 WP_000344807.1 NZ_CP074425:3411133-3411507 [Salmonella sp. SJTUF15034]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT202087 NZ_CP099310:c1043920-1043546 [Enterobacter ludwigii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACATCTGCCATCAATTTACAGTTAAACGAGTTGATCGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGATGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGCTACGGCATTAATGCGCAAGATTTGCAGAAATGGCGTAAATCGGGCAACCGACT
ATTTCGTTGCTTCATCAACGTGAGCAGAGCTAACCCCGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References