Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 987975..988789 Replicon chromosome
Accession NZ_CP074425
Organism Salmonella sp. SJTUF15034

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag KFD68_RS04720 Protein ID WP_000971655.1
Coordinates 987975..988502 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag KFD68_RS04725 Protein ID WP_000855694.1
Coordinates 988499..988789 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFD68_RS04695 (984264) 984264..984662 + 399 Protein_918 cytoplasmic protein -
KFD68_RS04700 (985248) 985248..985916 + 669 WP_000445914.1 hypothetical protein -
KFD68_RS04705 (985943) 985943..986437 + 495 WP_000424949.1 hypothetical protein -
KFD68_RS04710 (986682) 986682..987338 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
KFD68_RS04715 (987697) 987697..987902 + 206 Protein_922 IS5/IS1182 family transposase -
KFD68_RS04720 (987975) 987975..988502 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
KFD68_RS04725 (988499) 988499..988789 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
KFD68_RS04730 (989059) 989059..989248 - 190 Protein_925 IS3 family transposase -
KFD68_RS04735 (989652) 989652..990095 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
KFD68_RS04740 (990551) 990551..991201 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
KFD68_RS04745 (991198) 991198..992886 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 987726..987902 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T202076 WP_000971655.1 NZ_CP074425:c988502-987975 [Salmonella sp. SJTUF15034]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T202076 NZ_CP099308:c241863-241576 [Enterobacter roggenkampii]
ATGCATAACTTAACACCTTACGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAAAACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACGCTCAAACACGCCGGGGATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT202076 WP_000855694.1 NZ_CP074425:c988789-988499 [Salmonella sp. SJTUF15034]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT202076 NZ_CP099308:c242172-241870 [Enterobacter roggenkampii]
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGATCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTGGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCC
ACTTTGGTCCGGGCTACAGGATCTATTTTAAAGACCAGGGCAATTACATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References