Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 200177..200937 Replicon chromosome
Accession NZ_CP074425
Organism Salmonella sp. SJTUF15034

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag KFD68_RS00930 Protein ID WP_000533912.1
Coordinates 200452..200937 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag KFD68_RS00925 Protein ID WP_000965886.1
Coordinates 200177..200464 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFD68_RS00905 (195582) 195582..196493 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
KFD68_RS00910 (196503) 196503..198572 + 2070 WP_213680245.1 glycine--tRNA ligase subunit beta -
KFD68_RS23765 (198962) 198962..199360 + 399 Protein_181 IS3 family transposase -
KFD68_RS00920 (199532) 199532..199999 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
KFD68_RS00925 (200177) 200177..200464 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
KFD68_RS00930 (200452) 200452..200937 + 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
KFD68_RS00935 (201308) 201308..201847 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
KFD68_RS00940 (202021) 202021..202233 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
KFD68_RS00945 (202521) 202521..202811 - 291 WP_000455790.1 HTH-type transcriptional regulator -
KFD68_RS00950 (203250) 203250..203960 + 711 WP_000190524.1 DUF3053 domain-containing protein -
KFD68_RS00955 (204010) 204010..204984 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
KFD68_RS00960 (205203) 205203..205865 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T202071 WP_000533912.1 NZ_CP074425:200452-200937 [Salmonella sp. SJTUF15034]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T202071 NZ_CP099306:c4760235-4759978 [Klebsiella michiganensis]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATCCGCGATGCATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGTACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTACCGCATCAATACCACCGGGCTGAATAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT202071 WP_000965886.1 NZ_CP074425:200177-200464 [Salmonella sp. SJTUF15034]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT202071 NZ_CP099306:c4759967-4759416 [Klebsiella michiganensis]
ATGACAAACCACAGCTTCACTTTTCATGTCACCTCTGAAGGCGATACCGATGACATTCTCGACGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGTTATCGCTGCTGGCCA
GGCATAACGGAGAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGACGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGAGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCAATGGGAAGCCAGGCGGTATTTGTTCTGGGCCACGCCGCTTACTACCCCAGGCACGGGTTTGAGCCAGGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGCGGCGCATAAAGCCTGCTGGATGCTGCAGCCGATTTCGTCT
CAGCCGCTGGGACGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References