Detailed information of TA system TA202069

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 2205722..2206267
• Replicon: chromosome
• Accession: NZ_CP074415
• Organism: Vibrio parahaemolyticus strain 64

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: J5O00_RS10695
• Protein ID: WP_017420806.1
• Coordinates: 2205971..2206267 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: J5O00_RS10690
• Protein ID: WP_122015974.1
• Coordinates: 2205722..2205964 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5O00_RS10650	2200772..2200888	-	117	WP_172565420.1	DUF3265 domain-containing protein	-
J5O00_RS10655	2200885..2201208	-	324	WP_082798253.1	DUF4144 domain-containing protein	-
J5O00_RS26190	2201709..2201759	-	51	WP_229651053.1	hypothetical protein	-
J5O00_RS10665	2202175..2202264	-	90	WP_079740854.1	DUF3265 domain-containing protein	-
J5O00_RS10670	2202529..2202909	-	381	WP_219079171.1	hypothetical protein	-
J5O00_RS10675	2203492..2204349	-	858	WP_122015975.1	RNA helicase	-
J5O00_RS10680	2204395..2204502	-	108	Protein_2112	DUF3265 domain-containing protein	-
J5O00_RS26195	2204931..2205053	-	123	WP_257575542.1	DUF3265 domain-containing protein	-
J5O00_RS10685	2205050..2205505	-	456	WP_038964950.1	GNAT family N-acetyltransferase	-
J5O00_RS10690	2205722..2205964	+	243	WP_122015974.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
J5O00_RS10695	2205971..2206267	+	297	WP_017420806.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J5O00_RS10700	2206452..2206856	-	405	WP_038969946.1	DUF2007 domain-containing protein	-
J5O00_RS10705	2206963..2207877	-	915	WP_054730804.1	hypothetical protein	-
J5O00_RS10710	2208679..2209641	+	963	WP_021823496.1	integron integrase	-
J5O00_RS10715	2209702..2210175	-	474	WP_005458833.1	DUF2947 domain-containing protein	-
J5O00_RS10720	2210189..2210776	-	588	WP_029805496.1	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2096480..2211362	114882
	-	inside	Integron	-	-	2097514..2209641	112127

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-63)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11306.95 Da
• Isoelectric Point: 9.6425

>T202069 WP_017420806.1 NZ_CP074415:2205971-2206267 [Vibrio parahaemolyticus]
MQKNKYKLSKLAQTHLQKIRNYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Nucleotide

• Length: 297 bp

>T202069 NZ_CP099306:2249010-2249113 [Klebsiella michiganensis]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9001.19 Da
• Isoelectric Point: 5.0758

>AT202069 WP_122015974.1 NZ_CP074415:2205722-2205964 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLRHCFESAKQDLAQGNVVNGEDFLNAL

Nucleotide

• Length: 243 bp

>AT202069 NZ_CP099306:c2249120-2248952 [Klebsiella michiganensis]
AACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGTCCGCGACAAAAGTG
GACGAATAA