Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 2183433..2183980 Replicon chromosome
Accession NZ_CP074415
Organism Vibrio parahaemolyticus strain 64

Toxin (Protein)


Gene name relE Uniprot ID A0A2K7SRN5
Locus tag J5O00_RS10510 Protein ID WP_010448451.1
Coordinates 2183433..2183735 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag J5O00_RS10515 Protein ID WP_005448240.1
Coordinates 2183723..2183980 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5O00_RS10485 2179869..2180791 + 923 Protein_2070 IS5-like element ISVa2 family transposase -
J5O00_RS26160 2181359..2181424 - 66 Protein_2071 DUF3265 domain-containing protein -
J5O00_RS10490 2181421..2181780 - 360 WP_219079166.1 hypothetical protein -
J5O00_RS10495 2181800..2181892 - 93 Protein_2073 DUF3265 domain-containing protein -
J5O00_RS10500 2182494..2182697 - 204 WP_219079167.1 hypothetical protein -
J5O00_RS10505 2182834..2182959 - 126 WP_079882382.1 DUF3265 domain-containing protein -
J5O00_RS26165 2183359..2183436 - 78 Protein_2076 DUF3265 domain-containing protein -
J5O00_RS10510 2183433..2183735 - 303 WP_010448451.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J5O00_RS10515 2183723..2183980 - 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J5O00_RS26170 2184173..2184415 - 243 WP_257575202.1 hypothetical protein -
J5O00_RS10525 2184740..2185522 - 783 WP_023623900.1 hypothetical protein -
J5O00_RS10530 2185743..2186525 - 783 WP_023623899.1 hypothetical protein -
J5O00_RS26175 2186547..2186669 - 123 WP_079379530.1 DUF3265 domain-containing protein -
J5O00_RS10535 2186941..2187033 - 93 WP_079882431.1 DUF3265 domain-containing protein -
J5O00_RS26180 2187229..2187351 - 123 WP_257575203.1 hypothetical protein -
J5O00_RS10545 2187488..2187928 - 441 WP_021448683.1 hypothetical protein -
J5O00_RS10550 2188540..2188632 - 93 WP_005494807.1 DUF3265 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2096480..2211362 114882
- inside Integron - - 2097514..2209641 112127


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 11625.52 Da        Isoelectric Point: 5.1765

>T202068 WP_010448451.1 NZ_CP074415:c2183735-2183433 [Vibrio parahaemolyticus]
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLGKQ

Download         Length: 303 bp

>T202068 NZ_CP099306:2080864-2081196 [Klebsiella michiganensis]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCAGGCCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGTTACCCGTTGTTGTTCCCATCACCAGCGGCGGAAATTTTGCTCGCA
CGGCAGGTTTCACCGTTTCACTGGAAGGGGCAGGGATAAAAACGTTGGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGACTGCCCGGAACGGCAAGCGGCTGGAACGCATACCAGACGCTGTGGTAAATGAAGTGCTTGCCAGGCTGGATGC
AATTTTGAGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT202068 WP_005448240.1 NZ_CP074415:c2183980-2183723 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT202068 NZ_CP099306:2080606-2080863 [Klebsiella michiganensis]
ATGTATACCACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTCAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTCGGCATGACCATTAATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCTCATTATTCTC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCTCCTGCGGTG
GGCAAGGAGATCCTGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2K7SRN5


Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References