Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2149549..2150077 Replicon chromosome
Accession NZ_CP074415
Organism Vibrio parahaemolyticus strain 64

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag J5O00_RS10255 Protein ID WP_005377002.1
Coordinates 2149787..2150077 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag J5O00_RS10250 Protein ID WP_005377003.1
Coordinates 2149549..2149797 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5O00_RS10195 2144584..2144694 - 111 Protein_2008 DUF3265 domain-containing protein -
J5O00_RS10200 2144691..2145170 - 480 WP_023623400.1 hypothetical protein -
J5O00_RS10205 2145198..2145290 - 93 WP_005445734.1 DUF3265 domain-containing protein -
J5O00_RS10210 2145316..2145777 - 462 WP_023623399.1 hypothetical protein -
J5O00_RS10215 2145802..2146065 - 264 WP_219079153.1 hypothetical protein -
J5O00_RS10220 2146577..2146687 - 111 Protein_2013 DUF3265 domain-containing protein -
J5O00_RS10225 2146694..2146999 - 306 WP_238136529.1 GFA family protein -
J5O00_RS10230 2147268..2147621 - 354 WP_023623395.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
J5O00_RS10235 2147727..2148251 - 525 WP_023623394.1 hypothetical protein -
J5O00_RS10240 2148500..2148967 - 468 WP_023623393.1 ASCH domain-containing protein -
J5O00_RS26105 2148989..2149111 - 123 WP_079379530.1 DUF3265 domain-containing protein -
J5O00_RS10245 2149406..2149474 - 69 WP_074531725.1 DUF3265 domain-containing protein -
J5O00_RS10250 2149549..2149797 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J5O00_RS10255 2149787..2150077 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J5O00_RS10260 2150096..2150185 - 90 WP_077345960.1 DUF3265 domain-containing protein -
J5O00_RS10265 2150203..2150679 - 477 WP_025543523.1 GNAT family N-acetyltransferase -
J5O00_RS10270 2150822..2151247 - 426 WP_219079327.1 hypothetical protein -
J5O00_RS26110 2151240..2151305 - 66 Protein_2025 DUF3265 domain-containing protein -
J5O00_RS10275 2151781..2151873 - 93 WP_079751125.1 DUF3265 domain-containing protein -
J5O00_RS10280 2151976..2152344 + 369 WP_219079154.1 hypothetical protein -
J5O00_RS10285 2152421..2152513 - 93 WP_005445235.1 DUF3265 domain-containing protein -
J5O00_RS10290 2152995..2153228 - 234 WP_219079155.1 hypothetical protein -
J5O00_RS10295 2153837..2153965 - 129 WP_099098883.1 DUF3265 domain-containing protein -
J5O00_RS26115 2154390..2154467 - 78 WP_257575535.1 DUF3265 domain-containing protein -
J5O00_RS10305 2154613..2154759 + 147 WP_219079157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2096480..2211362 114882
- inside Integron - - 2097514..2209641 112127


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T202067 WP_005377002.1 NZ_CP074415:2149787-2150077 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T202067 NZ_CP099306:873759-874169 [Klebsiella michiganensis]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAGTGGTTTTCGCTGCTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGCTGATGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCAGGGAGAAATCAAGCTGCTGATCGACTCCCGTCTGCGCTGGCAAAAGGCG
GAGTGGGATATCATCGGCACCCCGTGGGTGATTAACAGCGGAATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGAAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGAGACCTGCGTCGGCTGGTGTTGCTAAAACCGA
CGCAAGAGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT202067 WP_005377003.1 NZ_CP074415:2149549-2149797 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT202067 NZ_CP099306:873512-873778 [Klebsiella michiganensis]
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGCCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTCAGCGATGGCGACAAAGCGTTATTCATCCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References