Detailed information of TA system TA202066

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2100386..2100914
• Replicon: chromosome
• Accession: NZ_CP074415
• Organism: Vibrio parahaemolyticus strain 64

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J5O00_RS09855
• Protein ID: WP_069514421.1
• Coordinates: 2100624..2100914 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR02
• Locus tag: J5O00_RS09850
• Protein ID: WP_005377003.1
• Coordinates: 2100386..2100634 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5O00_RS09815	2095919..2096365	+	447	WP_021449154.1	DUF3291 domain-containing protein	-
J5O00_RS09820	2096480..2096842	+	363	WP_023623457.1	VOC family protein	-
J5O00_RS09825	2097005..2097325	+	321	WP_241214658.1	GNAT family N-acetyltransferase	-
J5O00_RS26060	2097315..2097389	+	75	WP_254662690.1	hypothetical protein	-
J5O00_RS09830	2097514..2097861	-	348	WP_219079138.1	hypothetical protein	-
J5O00_RS09835	2098074..2098646	-	573	WP_069514418.1	hypothetical protein	-
J5O00_RS09840	2098799..2099197	-	399	WP_023623455.1	hypothetical protein	-
J5O00_RS09845	2099351..2100118	-	768	WP_257575192.1	zinc dependent phospholipase C family protein	-
J5O00_RS09850	2100386..2100634	+	249	WP_005377003.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
J5O00_RS09855	2100624..2100914	+	291	WP_069514421.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J5O00_RS09860	2101106..2101894	-	789	WP_238136516.1	HNH endonuclease signature motif containing protein	-
J5O00_RS09865	2101923..2102012	-	90	WP_072829120.1	DUF3265 domain-containing protein	-
J5O00_RS09870	2102534..2102623	-	90	Protein_1938	DUF3265 domain-containing protein	-
J5O00_RS09875	2102647..2103093	-	447	WP_023623451.1	hypothetical protein	-
J5O00_RS09880	2103236..2103652	-	417	WP_023623450.1	hypothetical protein	-
J5O00_RS26065	2104235..2104354	-	120	WP_257575532.1	DUF3265 domain-containing protein	-
J5O00_RS09890	2104384..2104650	-	267	WP_023623448.1	zinc ribbon domain-containing protein	-
J5O00_RS09895	2105139..2105564	-	426	WP_257575193.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2096480..2211362	114882
	-	inside	Integron	-	-	2097514..2209641	112127

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11276.27 Da
• Isoelectric Point: 10.6832

>T202066 WP_069514421.1 NZ_CP074415:2100624-2100914 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKSMKRLDN

Nucleotide

• Length: 291 bp

>T202066 NZ_CP099306:c58648-58340 [Klebsiella michiganensis]
ATGCAGTATTACGTTTATAAGAATACAGGTCGAATTGCTGCGTATCCTTACCTCCTTGATGTACAGAGTGACATTATCGG
CAAGCGCAATACTCGGGTCGTGATTCCACTGTTTCCACTGAAAAACTATAAAGGTCCACGCGCCGATCGTTTAACACCGC
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGCATCCCACATCGTGTTCTGGGTGAAGAA
GTTTGTAATCTGAATCACCAGCGCGAAGTCGTTAAAGCTTCAATGGATTTTCTTTTCGACGGGATCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9079.37 Da
• Isoelectric Point: 3.9610

>AT202066 WP_005377003.1 NZ_CP074415:2100386-2100634 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT202066 NZ_CP099306:c58887-58651 [Klebsiella michiganensis]
ATGCCAGCCGCAAAACGCAATAAGCAGAACGTCAGCGTGACACTGGACCCAGGCCTGGTCAAACAGGCTCGTGAGGTCGG
CATCAATCTGTCTCTAACGTTGACTAACGCTCTAAAAAGCGAAATCCACAGCCTCGAAATAGCCCGCTGGCAAAAAGAAA
ATGCCCAGGCAATCGACTACCTCAATAATTTAACTGAGGAAAATGGACTTCTCTCTGATGAATACAGGACGTTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A347UR02